12-(4-methylphenylsulfonyl)-5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine

Base Information

Chemical Name:12-(4-methylphenylsulfonyl)-5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine
CAS No.:76858-24-7
Molecular Formula:C₂₃H₂₁NO₂S
Molecular Weight:375.491
Hs Code.:

Synonyms:12-(4-methylphenylsulfonyl)-5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine

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Chemical Property of 12-(4-methylphenylsulfonyl)-5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine

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Technology Process of 12-(4-methylphenylsulfonyl)-5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine

There total 4 articles about 12-(4-methylphenylsulfonyl)-5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: N-(5-hydroxy-5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-10-yl)-4-methyl-benzenesulfonamide

: 76858-24-7
12-(4-methylphenylsulfonyl)-5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine

Guidance literature:: With boron trifluoride diethyl etherate; In dichloromethane; at 0 - 20 ℃; Inert atmosphere;
DOI:10.1016/j.tet.2012.03.007

Reference yield:

: 1372806-49-9
4-methyl-N-(5-oxo-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-10-yl)-benzenesulfonamide

: 76858-24-7
12-(4-methylphenylsulfonyl)-5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine

Guidance literature:: Multi-step reaction with 2 steps

1: tetrahydrofuran / 20 °C / Inert atmosphere; Cooling with ice

2: boron trifluoride diethyl etherate / dichloromethane / 0 - 20 °C / Inert atmosphere

With boron trifluoride diethyl etherate; In tetrahydrofuran; dichloromethane; 1: Grignard methylation;
DOI:10.1016/j.tet.2012.03.007

Reference yield:

: 127-65-1
chloroamine-T

: 76858-24-7
12-(4-methylphenylsulfonyl)-5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine

Guidance literature:: Multi-step reaction with 4 steps

1: N-Bromosuccinimide / acetonitrile / 10 h / Inert atmosphere; Reflux

2: palladium 10% on activated carbon; hydrogen / methanol / 10 h / 20 °C

3: tetrahydrofuran / 20 °C / Inert atmosphere; Cooling with ice

4: boron trifluoride diethyl etherate / dichloromethane / 0 - 20 °C / Inert atmosphere

With N-Bromosuccinimide; palladium 10% on activated carbon; boron trifluoride diethyl etherate; hydrogen; In tetrahydrofuran; methanol; dichloromethane; acetonitrile; 3: Grignard methylation;
DOI:10.1016/j.tet.2012.03.007