2-Methyl-1,2-diphenyl-1-propanone

Base Information

• Chemical Name: 2-Methyl-1,2-diphenyl-1-propanone
• CAS No.: 13740-70-0
• Molecular Formula: C16H16 O
• Molecular Weight: 224.302
• Hs Code.: 2914399090
• DSSTox Substance ID: DTXSID00160173
• Nikkaji Number: J378.003A
• Wikidata: Q83028545
• Mol file: 13740-70-0.mol

Synonyms:2-MDPP;2-methyl-1,2-diphenyl-1-propanone;2-methyl-1,2-diphenyl-1-propanone, 1-(13)-C-labeled

Chemical Property of 2-Methyl-1,2-diphenyl-1-propanone

Chemical Property:

• Vapor Pressure: 0.000111mmHg at 25°C
• Boiling Point: 336.6°Cat760mmHg
• Flash Point: 143°C
• PSA: 17.07000
• Density: 1.04g/cm³
• LogP: 3.84710
• XLogP3: 4.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 3
• Exact Mass: 224.120115130
• Heavy Atom Count: 17
• Complexity: 255

Purity/Quality:

99%min ^*data from raw suppliers

2-METHYL-1,2-DIPHENYL-1-PROPANONE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC(C)(C1=CC=CC=C1)C(=O)C2=CC=CC=C2

Technology Process of 2-Methyl-1,2-diphenyl-1-propanone

There total 51 articles about 2-Methyl-1,2-diphenyl-1-propanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

2-methyl-1-phenyl-1-trimethylsiloxy-1-propene (39158-85-5) → 2-methyl-1,2-diphenyl-propan-1-one (13740-70-0)

Guidance literature:

In tetrahydrofuran; at -40 - 20 ℃; for 1h;

DOI:10.1021/ja030150k

Reference yield: 92.0%

bromobenzene (108-86-1,52753-63-6) + phenyl isopropyl ketone (611-70-1) → 2-methyl-1,2-diphenyl-propan-1-one (13740-70-0)

Guidance literature:

With palladium diacetate; tri-tert-butyl phosphine; sodium t-butanolate; In tetrahydrofuran; at 50 ℃; for 12h;

DOI:10.1021/ja983378u

Reference yield: 76.0%

1,3-dioxoisoindolin-2-yl 2-methyl-2-phenylpropanoate (2241846-03-5) + benzaldehyde (100-52-7) → 2-methyl-1,2-diphenyl-propan-1-one (13740-70-0)

Guidance literature:

With 3-(2,6-diisopropylphenyl)-5,6,7,8-tetrahydro-4H-cyclohepta[d]thiazol-3-ium perchlorate; caesium carbonate; In dimethyl sulfoxide; at 60 ℃; for 4h; Inert atmosphere; Schlenk technique; Sealed tube;

DOI:10.1021/jacs.9b00880

upstream raw materials:

2-methyl-2-phenylpropionitrile

2-methyl-1,1-diphenylpropane-1,2-diol

2,3-diphenyl-2,3-butanediol

1,2-diphenylpropan-1-one

Downstream raw materials:

1,2-diphenyl-2-methylpropane-1-ol

2,3-diphenyl-2-methylpropan-3-one oxime

cumyl peroxy radical

2-(4-amino-phenyl)-2-methyl-1-phenyl-propan-1-one

Refernces

• 1、 Ishii, Takuya,Kakeno, Yuki,Nagao, Kazunori,Ohmiya, Hirohisa. "N-Heterocyclic Carbene-Catalyzed Decarboxylative Alkylation of Aldehydes". supporting information. p. 3854 - 3858. Retrieved 2019/04/25.
• 2、 Gómez-Martínez, Melania,Baeza, Alejandro,Alonso, Diego A.. "Pinacol Rearrangement and Direct Nucleophilic Substitution of Allylic Alcohols Promoted by Graphene Oxide and Graphene Oxide CO2H". . p. 1032 - 1039. Retrieved 2017/03/27.