Racemoramide

Base Information

• Chemical Name: Racemoramide
• CAS No.: 545-59-5
• Deprecated CAS: 13013-15-5
• Molecular Formula: C25H32 N2 O2
• Molecular Weight: 392.541
• European Community (EC) Number: 208-893-0
• UNII: L3J8QT828G
• DSSTox Substance ID: DTXSID50859343
• Wikipedia: Racemoramide
• Wikidata: Q7279008
• NCI Thesaurus Code: C76845
• ChEMBL ID: CHEMBL431928
• Mol file: 545-59-5.mol

Synonyms:D Moramide;D-Moramide;Dextromoramide;Dextromoramide Tartrate;Palfium;Pyrrolamidol;Tartrate, Dextromoramide

 This product is a nationally controlled contraband, and the Lookchem platform doesn't provide relevant sales information.

Chemical Property of Racemoramide

Chemical Property:

• Melting Point: 170-172 °C
• Boiling Point: 579.6±50.0 °C(Predicted)
• PKA: 6.90±0.10(Predicted)
• PSA: 32.78000
• Density: 1.121±0.06 g/cm3(Predicted)
• LogP: 3.43920
• XLogP3: 3.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 6
• Exact Mass: 392.246378268
• Heavy Atom Count: 29
• Complexity: 495

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(CN1CCOCC1)C(C2=CC=CC=C2)(C3=CC=CC=C3)C(=O)N4CCCC4
• Uses: The racemic Moramide. (S)-Moramide or Dextromoramide is a controlled substance (opiate). Analgesic (narcotic).

Technology Process of Racemoramide

There total 3 articles about Racemoramide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-(2-chloro-propyl)-morpholine (41821-45-8) + N-(2,2-diphenylacetyl)pyrrolidine (60678-46-8) → 1-(4-morpholin-4-yl-2,2-diphenyl-pentanoyl)-pyrrolidine (66626-38-8) + dextromoramide (545-59-5,13013-15-5)

Guidance literature:

With sodium oxide;

DOI:10.1021/ja01596a087

Reference yield:

pyrrolidine (123-75-1) → dextromoramide (545-59-5,13013-15-5)

Guidance literature:

With benzene;

Reference yield:

→ dextromoramide (545-59-5,13013-15-5)

Guidance literature:

Diphenylessigsaeure-pyrrolid 1. NaOEt 2. 2-Chlor-1-morpholino-propan (neben 1-Oxo-2,2-diphenyl-1-pyrrolidino-4-morpholino-pentan);

upstream raw materials:

4-(2-chloro-propyl)-morpholine

N-(2,2-diphenylacetyl)pyrrolidine

pyrrolidine