2,2-diphenyl-1-pyrrolidin-1-ylethanone

Base Information

• Chemical Name: 2,2-diphenyl-1-pyrrolidin-1-ylethanone
• CAS No.: 60678-46-8
• Molecular Formula: C18H19NO
• Molecular Weight: 265.355
• Mol file: 60678-46-8.mol

Synonyms:1-Diphenylacetyl-pyrrolidin;N-(diphenylacetyl)pyrrolidine;Diphenylacetylpyrrolidine;1-(Diphenylacetyl)pyrrolidine;Diphenylessigsaeure-pyrrolidid;N-(2,2-diphenylacetyl)pyrrolidine;

Chemical Property of 2,2-diphenyl-1-pyrrolidin-1-ylethanone

Chemical Property:

• PSA: 20.31000
• LogP: 3.37880

Purity/Quality:

2,2-DIPHENYL-1-PYRROLIDIN-1-YL-ETHANONE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,2-diphenyl-1-pyrrolidin-1-ylethanone

There total 3 articles about 2,2-diphenyl-1-pyrrolidin-1-ylethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

pyrrolidine (123-75-1) + methyl 2,2-diphenylacetate (3469-00-9) → N-(2,2-diphenylacetyl)pyrrolidine (60678-46-8)

Guidance literature:

With bis(trimethylaluminum)–1,4-diazabicyclo[2.2.2]octane adduct; In tetrahydrofuran; at 130 ℃; for 0.133333h; Inert atmosphere; Microwave irradiation;

DOI:10.1016/j.tet.2013.08.062

Reference yield:

pyrrolidine (123-75-1) + diphenylacetic acid chloride (1871-76-7) → N-(2,2-diphenylacetyl)pyrrolidine (60678-46-8)

Guidance literature:

With acetone;

DOI:10.1021/jo01086a005

Reference yield:

→ N-(2,2-diphenylacetyl)pyrrolidine (60678-46-8)

Guidance literature:

3-Pyrrolidino-4,4-dimethyl-2,2-diphenyl-cyclobutanon-(1), sd. Me. od. Bzl. (12 h) (neben Isopropyl-benzhydryl-keton);

upstream raw materials:

pyrrolidine

diphenylacetic acid chloride

methyl 2,2-diphenylacetate

Downstream raw materials:

diphenamid

2-[4-(Dimethylcarbamoyl-phenyl-methyl)-phenyl]-N,N-dimethyl-2,2-diphenyl-acetamide

N,N-Dimethyl-2-[4-(2-oxo-1,1-diphenyl-2-pyrrolidin-1-yl-ethyl)-phenyl]-2-phenyl-acetamide

N,N-Dimethyl-2-[4-(2-oxo-1-phenyl-2-pyrrolidin-1-yl-ethyl)-phenyl]-2,2-diphenyl-acetamide

Refernces