Acetamide, N-(5,6,7,8-tetrahydro-6-hydroxy-7-(4-phenyl-1-piperidinyl)-1-naphthalenyl)-trans-(+-)-

Base Information

Chemical Name:Acetamide, N-(5,6,7,8-tetrahydro-6-hydroxy-7-(4-phenyl-1-piperidinyl)-1-naphthalenyl)-trans-(+-)-
CAS No.:120447-37-2
Molecular Formula:C₂₃H₂₈N₂O₂
Molecular Weight:364.488
Hs Code.:
DSSTox Substance ID:DTXSID10152867
Wikidata:Q76279480

Synonyms:trans-(+-)-5-Acetamido-2-hydroxy-3-(4-phenylpiperidino)tetralin;Acetamide, N-(5,6,7,8-tetrahydro-6-hydroxy-7-(4-phenyl-1-piperidinyl)-1-naphthalenyl)-trans-(+-)-;120447-37-2;DTXSID10152867

Suppliers and Price of Acetamide, N-(5,6,7,8-tetrahydro-6-hydroxy-7-(4-phenyl-1-piperidinyl)-1-naphthalenyl)-trans-(+-)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 1 raw suppliers

Chemical Property of Acetamide, N-(5,6,7,8-tetrahydro-6-hydroxy-7-(4-phenyl-1-piperidinyl)-1-naphthalenyl)-trans-(+-)-

Chemical Property:

Vapor Pressure:1.1E-14mmHg at 25°C
Boiling Point:588.3°C at 760 mmHg
Flash Point:309.6°C
Density:1.208g/cm³
XLogP3:3.1
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:364.215078140
Heavy Atom Count:27
Complexity:497

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(=O)NC1=CC=CC2=C1CC(C(C2)O)N3CCC(CC3)C4=CC=CC=C4
Isomeric SMILES:CC(=O)NC1=CC=CC2=C1C[C@@H]([C@H](C2)O)N3CCC(CC3)C4=CC=CC=C4

Technology Process of Acetamide, N-(5,6,7,8-tetrahydro-6-hydroxy-7-(4-phenyl-1-piperidinyl)-1-naphthalenyl)-trans-(+-)-

There total 5 articles about Acetamide, N-(5,6,7,8-tetrahydro-6-hydroxy-7-(4-phenyl-1-piperidinyl)-1-naphthalenyl)-trans-(+-)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 23.0%

: 771-99-3
4-phenylpiperidine

: 861057-68-3
N-(6,7-epoxy-5,6,7,8-tetrahydro-[1]naphthyl)-acetamide

: 120447-37-2
(+/-)-trans-5-acetamido-2-hydroxy-3-(4-phenylpiperidino)tetralin

: (+/-)-trans-5-acetamido-3-hydroxy-2-(4-phenylpiperidino)tetralin

Guidance literature:: In ethanol; a) 45 deg C, 17 h, b) reflux, 3 h, c) 23 deg C, 7 h;
DOI:10.1021/jm00126a013

Reference yield:

: 32666-56-1
1-amino-5,8-dihydronaphthalene

: 120447-37-2
(+/-)-trans-5-acetamido-2-hydroxy-3-(4-phenylpiperidino)tetralin

Guidance literature:: Multi-step reaction with 3 steps

1: benzene / 1 h / 0 °C

2: 80-85percent 3-chloroperoxybenzoic acid / diethyl ether / 5 h / 23 °C

3: 32 percent / ethanol / a) 45 deg C, 17 h, b) reflux, 3 h, c) 23 deg C, 7 h

With 3-chloro-benzenecarboperoxoic acid; In diethyl ether; ethanol; benzene;
DOI:10.1021/jm00126a013

Reference yield:

: 115348-05-5
1-acetamido-5,8-dihydronaphthalene

: 120447-37-2
(+/-)-trans-5-acetamido-2-hydroxy-3-(4-phenylpiperidino)tetralin

Guidance literature:: Multi-step reaction with 2 steps

1: 80-85percent 3-chloroperoxybenzoic acid / diethyl ether / 5 h / 23 °C

2: 32 percent / ethanol / a) 45 deg C, 17 h, b) reflux, 3 h, c) 23 deg C, 7 h

With 3-chloro-benzenecarboperoxoic acid; In diethyl ether; ethanol;
DOI:10.1021/jm00126a013