N-Phenyl-N-phenylacetylaminophenylacetic acid methyl ester

Base Information

• Chemical Name: N-Phenyl-N-phenylacetylaminophenylacetic acid methyl ester
• CAS No.: 83529-25-3
• Molecular Formula: C₂₃H₂₁NO₃
• Molecular Weight: 359.425
• DSSTox Substance ID: DTXSID701003521
• Nikkaji Number: J127.633F
• Mol file: 83529-25-3.mol

Synonyms:83529-25-3;N-Phenyl-N-phenylacetylaminophenylacetic acid methyl ester;N,2-Diphenyl-N-(phenylacetyl)glycine methyl ester;Glycine, N,2-diphenyl-N-(phenylacetyl)-, methyl ester;METHYL 2-PHENYL-2-[PHENYL-(2-PHENYLACETYL)AMINO]ACETATE;Benzeneacetic acid, alpha-(phenyl(phenylacetyl)amino)-, methyl ester;C23H21NO3;DTXSID701003521;C23-H21-N-O3;LS-72610;Methyl phenyl[phenyl(phenylacetyl)amino]acetate

Chemical Property of N-Phenyl-N-phenylacetylaminophenylacetic acid methyl ester

Chemical Property:

• Vapor Pressure: 8.86E-11mmHg at 25°C
• Boiling Point: 516.6°C at 760 mmHg
• Flash Point: 266.2°C
• Density: 1.199g/cm³
• XLogP3: 4.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 7
• Exact Mass: 359.15214353
• Heavy Atom Count: 27
• Complexity: 474

Purity/Quality:

85.0-99.8% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC(=O)C(C1=CC=CC=C1)N(C2=CC=CC=C2)C(=O)CC3=CC=CC=C3

Technology Process of N-Phenyl-N-phenylacetylaminophenylacetic acid methyl ester

There total 1 articles about N-Phenyl-N-phenylacetylaminophenylacetic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

methyl 2-phenyl-2-(phenylamino)acetate (64464-76-2,85893-65-8,119566-46-0) + phenylacetyl chloride (103-80-0) → Phenyl-(phenyl-phenylacetyl-amino)-acetic acid methyl ester (83529-25-3)

Guidance literature:

With sodium iodide; In benzene; 1.) overnight, 2.) reflux, 18 h;

DOI:10.1007/BF00761542

Reference yield: 91.9%

Phenyl-(phenyl-phenylacetyl-amino)-acetic acid methyl ester (83529-25-3) → N-Phenyl-N-phenacetylphenylacetic acid (83529-28-6)

Guidance literature:

With potassium hydroxide; for 8h; Heating;

DOI:10.1007/BF00761542

Reference yield:

Phenyl-(phenyl-phenylacetyl-amino)-acetic acid methyl ester (83529-25-3) → N-Phenyl-N-phenacetylphenylacetic acid ethyl ester (83529-30-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 91.9 percent / 15percent aq. KOH / 8 h / Heating

2: 77.1 percent / HCl / 1.) 6 h, 2.) 3-4 h

With hydrogenchloride; potassium hydroxide;

DOI:10.1007/BF00761542

upstream raw materials:

methyl 2-phenyl-2-(phenylamino)acetate

phenylacetyl chloride

Downstream raw materials:

N-Phenyl-N-phenacetylphenylacetic acid

N-Phenyl-N-phenacetylphenylacetic acid ethyl ester