N,2-Diphenyl-N-(phenylacetyl)glycine ethyl ester

Base Information

• Chemical Name: N,2-Diphenyl-N-(phenylacetyl)glycine ethyl ester
• CAS No.: 83529-30-0
• Molecular Formula: C₂₄H₂₃NO₃
• Molecular Weight: 373.452
• DSSTox Substance ID: DTXSID501003525
• Nikkaji Number: J127.632H
• Mol file: 83529-30-0.mol

Synonyms:N,2-Diphenyl-N-(phenylacetyl)glycine ethyl ester;N-Phenyl-N-phenacetylphenylacetic acid ethyl ester;Glycine, N,2-diphenyl-N-(phenylacetyl)-, ethyl ester;Benzeneacetic acid, alpha-(phenyl(phenylacetyl)amino)-, ethyl ester;83529-30-0;DTXSID501003525;LS-72609;Ethyl phenyl[phenyl(phenylacetyl)amino]acetate

Chemical Property of N,2-Diphenyl-N-(phenylacetyl)glycine ethyl ester

Chemical Property:

• Vapor Pressure: 3.38E-11mmHg at 25°C
• Boiling Point: 527°C at 760 mmHg
• Flash Point: 272.5°C
• Density: 1.181g/cm³
• XLogP3: 4.9
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 8
• Exact Mass: 373.16779360
• Heavy Atom Count: 28
• Complexity: 488

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC(=O)C(C1=CC=CC=C1)N(C2=CC=CC=C2)C(=O)CC3=CC=CC=C3

Technology Process of N,2-Diphenyl-N-(phenylacetyl)glycine ethyl ester

There total 4 articles about N,2-Diphenyl-N-(phenylacetyl)glycine ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.1%

ethanol (64-17-5) + N-Phenyl-N-phenacetylphenylacetic acid (83529-28-6) → N-Phenyl-N-phenacetylphenylacetic acid ethyl ester (83529-30-0)

Guidance literature:

With hydrogenchloride; 1.) 6 h, 2.) 3-4 h;

DOI:10.1007/BF00761542

Reference yield:

methyl 2-phenyl-2-(phenylamino)acetate (64464-76-2,85893-65-8,119566-46-0) → N-Phenyl-N-phenacetylphenylacetic acid ethyl ester (83529-30-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 65 percent / NaI / benzene / 1.) overnight, 2.) reflux, 18 h

2: 91.9 percent / 15percent aq. KOH / 8 h / Heating

3: 77.1 percent / HCl / 1.) 6 h, 2.) 3-4 h

With hydrogenchloride; potassium hydroxide; sodium iodide; In benzene;

DOI:10.1007/BF00761542

Reference yield:

phenylacetyl chloride (103-80-0) → N-Phenyl-N-phenacetylphenylacetic acid ethyl ester (83529-30-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 65 percent / NaI / benzene / 1.) overnight, 2.) reflux, 18 h

2: 91.9 percent / 15percent aq. KOH / 8 h / Heating

3: 77.1 percent / HCl / 1.) 6 h, 2.) 3-4 h

With hydrogenchloride; potassium hydroxide; sodium iodide; In benzene;

DOI:10.1007/BF00761542

upstream raw materials:

ethanol

N-Phenyl-N-phenacetylphenylacetic acid

Phenyl-(phenyl-phenylacetyl-amino)-acetic acid methyl ester

methyl 2-phenyl-2-(phenylamino)acetate