2,5-Methano-5H,9H-pyrimido[2,1-b][1,5,3]dioxazepin-9-one, 2,3-dihydro-8-iodo-3-[(triphenylmethoxy)methyl]-, (2R,3R,5R)-

Base Information

Chemical Name:2,5-Methano-5H,9H-pyrimido[2,1-b][1,5,3]dioxazepin-9-one, 2,3-dihydro-8-iodo-3-[(triphenylmethoxy)methyl]-, (2R,3R,5R)-
CAS No.:101039-85-4
Molecular Formula:C28H23IN2O4
Molecular Weight:578.406
Hs Code.:
Mol file:101039-85-4.mol

Synonyms:

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Chemical Property of 2,5-Methano-5H,9H-pyrimido[2,1-b][1,5,3]dioxazepin-9-one, 2,3-dihydro-8-iodo-3-[(triphenylmethoxy)methyl]-, (2R,3R,5R)-

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MSDS Files:: SDS file from LookChem

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Technology Process of 2,5-Methano-5H,9H-pyrimido[2,1-b][1,5,3]dioxazepin-9-one, 2,3-dihydro-8-iodo-3-[(triphenylmethoxy)methyl]-, (2R,3R,5R)-

There total 5 articles about 2,5-Methano-5H,9H-pyrimido[2,1-b][1,5,3]dioxazepin-9-one, 2,3-dihydro-8-iodo-3-[(triphenylmethoxy)methyl]-, (2R,3R,5R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 101039-82-1
5-iodo-3'-O-mesyl-5'-O-trityl-2'-deoxyuridine

: 101039-85-4
2,3'-anydro-5-iodo-5'-O-trityl-2'-deoxyuridine

Guidance literature:: With sodium hydroxide; In ethanol; for 0.5h; Heating;
DOI:10.1016/j.bmc.2005.07.046

Reference yield: 25.0%

: 101039-82-1
5-iodo-3'-O-mesyl-5'-O-trityl-2'-deoxyuridine

: 101039-83-2
2,3'-anhydro-3-(5-O-trityl-2,3-dideoxy-β-D-threo-pentofuranosyl)-5-iodouracil

: 101039-85-4
2,3'-anydro-5-iodo-5'-O-trityl-2'-deoxyuridine

: 1-(3-azido-2,3-dideoxy-5-O-trityl-β-D-threo-pentofuranosyl)-5-iodouracil

: 87190-83-8
1-(3-azido-2,3-dideoxy-5-O-trityl-β-D-erythro-pentofuranosyl)-5-iodouracil

Guidance literature:: With lithium azide; In N,N-dimethyl-formamide; at 100 ℃; for 5h;

Reference yield:

: 54-42-2,162239-35-2
5-Iodo-2'-deoxyuridine

: 101039-85-4
2,3'-anydro-5-iodo-5'-O-trityl-2'-deoxyuridine

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine / 6 h / 45 °C

2: 1.6 g / pyridine / 1.5 h / 25 °C

3: 82 percent / sodium hydroxide / ethanol / 0.5 h / Heating

With pyridine; sodium hydroxide; In ethanol;
DOI:10.1016/j.bmc.2005.07.046