(5-Amino-2-chloro-4-fluorophenyl)methanol

Base Information

Chemical Name:(5-Amino-2-chloro-4-fluorophenyl)methanol
CAS No.:101329-82-2
Molecular Formula:C7H7ClFNO
Molecular Weight:175.59
Hs Code.:
DSSTox Substance ID:DTXSID00545441
Wikidata:Q82422937
Mol file:101329-82-2.mol

Synonyms:(5-Amino-2-chloro-4-fluorophenyl)methanol;101329-82-2;Benzenemethanol, 5-amino-2-chloro-4-fluoro-;SCHEMBL8879998;DTXSID00545441;QEXZLRPDTPQYHC-UHFFFAOYSA-N;2-chloro-4-fluoro-5-aminobenzyl alcohol;CS-0380075;5-AMINO-2-CHLORO-4-FLUOROBENZYL ALCOHOL

Suppliers and Price of (5-Amino-2-chloro-4-fluorophenyl)methanol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of (5-Amino-2-chloro-4-fluorophenyl)methanol

Chemical Property:

XLogP3:1.1
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:175.0200197
Heavy Atom Count:11
Complexity:136

Purity/Quality:: 95% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=C(C(=CC(=C1N)F)Cl)CO

Technology Process of (5-Amino-2-chloro-4-fluorophenyl)methanol

There total 4 articles about (5-Amino-2-chloro-4-fluorophenyl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 101329-81-1
2-chloro-4-fluoro-5-nitrobenzenemethanol

: 101329-82-2
2-Chloro-4-fluoro-5-aminobenzyl alcohol

Guidance literature:: With tin(ll) chloride; In ethanol; at 70 ℃; for 2h;
DOI:10.1055/s-1987-28110

Reference yield:

: 452-73-3
2-chloro-4-fluorotoluene

: 101329-82-2
2-Chloro-4-fluoro-5-aminobenzyl alcohol

Guidance literature:: Multi-step reaction with 4 steps

1: 92 percent / Co(OAc)2*4H₂O, Mn(OAc)2*4H₂O, tert-butyl peroxide, 48percent HBr, O₂ / acetic acid / 3 h / 130 - 160 °C / 15514.4 Torr

2: 83 percent / fuming HNO₃, conc. H₂SO₄ / 0 deg C, 1 h then 50 deg C, 1.5 h

3: 93 percent / B₂H₆ / tetrahydrofuran / 1.5 h / Heating

4: 68 percent / SnCl₂*2H₂O / ethanol / 2 h / 70 °C

With di-tert-butyl peroxide; sulfuric acid; hydrogen bromide; oxygen; nitric acid; cobalt(II) acetate; manganese(II) acetate; tin(ll) chloride; diborane; In tetrahydrofuran; ethanol; acetic acid;
DOI:10.1055/s-1987-28110

Reference yield:

: 2252-51-9
2-choro-4-fluorobenzoic acid

: 101329-82-2
2-Chloro-4-fluoro-5-aminobenzyl alcohol

Guidance literature:: Multi-step reaction with 3 steps

1: 83 percent / fuming HNO₃, conc. H₂SO₄ / 0 deg C, 1 h then 50 deg C, 1.5 h

2: 93 percent / B₂H₆ / tetrahydrofuran / 1.5 h / Heating

3: 68 percent / SnCl₂*2H₂O / ethanol / 2 h / 70 °C

With sulfuric acid; nitric acid; tin(ll) chloride; diborane; In tetrahydrofuran; ethanol;
DOI:10.1055/s-1987-28110