Ethyl 4-oxo-2,6-diphenylpiperidine-3-carboxylate

Base Information

Chemical Name:Ethyl 4-oxo-2,6-diphenylpiperidine-3-carboxylate
CAS No.:102012-64-6
Molecular Formula:C20H21NO3
Molecular Weight:323.392
Hs Code.:
DSSTox Substance ID:DTXSID70561355
Mol file:102012-64-6.mol

Synonyms:Ethyl 4-oxo-2,6-diphenylpiperidine-3-carboxylate;102012-64-6;SCHEMBL15750255;DTXSID70561355;2,6-diphenyl-3-carboethoxypiperidine-4-one

Suppliers and Price of Ethyl 4-oxo-2,6-diphenylpiperidine-3-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
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Chemical Property of Ethyl 4-oxo-2,6-diphenylpiperidine-3-carboxylate

Chemical Property:

Boiling Point:474.6±45.0 °C(Predicted)
PSA：55.40000
Density:1.148±0.06 g/cm3(Predicted)
LogP:3.53950
XLogP3:2.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:5
Exact Mass:323.15214353
Heavy Atom Count:24
Complexity:438

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC(=O)C1C(NC(CC1=O)C2=CC=CC=C2)C3=CC=CC=C3

Technology Process of Ethyl 4-oxo-2,6-diphenylpiperidine-3-carboxylate

There total 5 articles about Ethyl 4-oxo-2,6-diphenylpiperidine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 141-97-9
ethyl acetoacetate

: 100-52-7
benzaldehyde

: 102012-64-6
2,6-diphenyl-3-ethoxycarbonylpiperidin-4-one

Guidance literature:: With SILPOC; ammonia; at 60 ℃; for 1.16667h;
DOI:10.1071/CH15133

Reference yield: 50.0%

: 132330-15-5
2,6-diphenyl-3-carboethoxy-4-amino-1,2,5,6-tetrahydropyridine

: 102012-64-6
2,6-diphenyl-3-ethoxycarbonylpiperidin-4-one

Guidance literature:: With sulfuric acid; at 20 ℃; for 12h;
DOI:10.1007/BF00772137

Reference yield:

: 135900-95-7
2,6-diphenyl-3-carboethoxy-4-iminopiperidine

: 102012-64-6
2,6-diphenyl-3-ethoxycarbonylpiperidin-4-one

Guidance literature:: Multi-step reaction with 2 steps

1: 27 percent / aq. NH₃ / ethanol

2: 50 percent / conc. H₂SO₄ / 12 h / 20 °C

With ammonium hydroxide; sulfuric acid; In ethanol;
DOI:10.1007/BF00772137