N-chloroacetyl-3-carboxyethyl-2,6-diphenyl-4-hydroxy-Δ3-tetrahydropyridine

Base Information

• Chemical Name: N-chloroacetyl-3-carboxyethyl-2,6-diphenyl-4-hydroxy-Δ3-tetrahydropyridine
• CAS No.: 1103231-24-8
• Molecular Formula: C₂₂H₂₂ClNO₄
• Molecular Weight: 399.874

Synonyms:N-chloroacetyl-3-carboxyethyl-2,6-diphenyl-4-hydroxy-Δ3-tetrahydropyridine

Chemical Property of N-chloroacetyl-3-carboxyethyl-2,6-diphenyl-4-hydroxy-Δ3-tetrahydropyridine

Chemical Property:

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Technology Process of N-chloroacetyl-3-carboxyethyl-2,6-diphenyl-4-hydroxy-Δ3-tetrahydropyridine

There total 1 articles about N-chloroacetyl-3-carboxyethyl-2,6-diphenyl-4-hydroxy-Δ3-tetrahydropyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

2,6-diphenyl-3-ethoxycarbonylpiperidin-4-one (102012-64-6) + chloroacetyl chloride (79-04-9) → N-chloroacetyl-3-carboxyethyl-2,6-diphenyl-4-hydroxy-Δ3-tetrahydropyridine (1103231-24-8)

Guidance literature:

With triethylamine; In benzene; at 20 ℃; for 4h;

DOI:10.1016/j.bmcl.2008.10.045

Reference yield: 90.0%

benzoimidazole (51-17-2,79351-71-6) + N-chloroacetyl-3-carboxyethyl-2,6-diphenyl-4-hydroxy-Δ3-tetrahydropyridine (1103231-24-8) → 1-[2-(1H-benzimidazol-1-yl)acetyl]-3-carboxyethyl-2,6-diphenyl-4-hydroxy-Δ3-tetrahydropyridine (1103231-27-1)

Guidance literature:

With potassium carbonate; In benzene; for 7h; Reflux;

DOI:10.1016/j.bmcl.2008.10.045

Reference yield: 74.0%

N-chloroacetyl-3-carboxyethyl-2,6-diphenyl-4-hydroxy-Δ3-tetrahydropyridine (1103231-24-8) + 4-Nitrobenzenesulfonyl chloride (98-74-8) → N-chloroacetyl-3-carboxyethyl-2,6-diphenyl-4-O-(4-nitro-benzenesulfonyl)-Δ3-tetrahydropyridine (1103231-33-9)

Guidance literature:

With dmap; In dichloromethane; at 20 ℃;

DOI:10.1016/j.bmcl.2008.10.045

upstream raw materials:

2,6-diphenyl-3-ethoxycarbonylpiperidin-4-one

chloroacetyl chloride

Downstream raw materials:

1-[2-(1H-benzimidazol-1-yl)acetyl]-3-carboxyethyl-2,6-diphenyl-4-hydroxy-Δ3-tetrahydropyridine

N-chloroacetyl-3-carboxyethyl-2,6-diphenyl-4-O-(thiophen-2-sulfonyl)-Δ3-tetrahydropyridine

N-chloroacetyl-3-carboxyethyl-2,6-diphenyl-4-O-(4-vinyl-benzenesulfonyl)-Δ3-tetrahydropyridine

N-chloroacetyl-3-carboxyethyl-2,6-diphenyl-4-O-(2-nitro-benzenesulfonyl)-Δ3-tetrahydropyridine

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