1-(2-PHENYL-1H-INDOL-3-YL)-2-PIPERIDINO-1,2-ETHANEDIONE

Base Information

• Chemical Name: 1-(2-PHENYL-1H-INDOL-3-YL)-2-PIPERIDINO-1,2-ETHANEDIONE
• CAS No.: 102318-27-4
• Molecular Formula: C21H20N2O2
• Molecular Weight: 332.39600
• Mol file: 102318-27-4.mol

Synonyms:1-(2-Phenyl-1H-indol-3-yl)-2-piperidin-1-yl-ethane-1,2-dione;(2-Phenyl-indol-3-yl)-glyoxylsaeure-piperidid;

Chemical Property of 1-(2-PHENYL-1H-INDOL-3-YL)-2-PIPERIDINO-1,2-ETHANEDIONE

Chemical Property:

• PSA: 53.17000
• LogP: 3.96800

Purity/Quality:

97% ^*data from raw suppliers

1-(2-Phenyl-1H-indol-3-yl)-2-piperidino-1,2-ethanedione ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(2-PHENYL-1H-INDOL-3-YL)-2-PIPERIDINO-1,2-ETHANEDIONE

There total 3 articles about 1-(2-PHENYL-1H-INDOL-3-YL)-2-PIPERIDINO-1,2-ETHANEDIONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

piperidine (110-89-4) + 2-oxo-(2-phenyl-1H-indol-3-yl)acetyl chloride (4560-08-1) → (2-phenyl-indol-3-yl)-glyoxylic acid piperidide (102318-27-4)

Guidance literature:

With triethylamine; In toluene; at 20 ℃;

DOI:10.1021/jm030973k

Reference yield:

2-phenyl-indole (948-65-2) → (2-phenyl-indol-3-yl)-glyoxylic acid piperidide (102318-27-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 68 percent / diethyl ether / 20 °C

2: triethylamine / toluene / 20 °C

With triethylamine; In diethyl ether; toluene;

DOI:10.1021/jm030973k

Reference yield:

2-phenyl-indole (948-65-2) + oxalyl dichloride (79-37-8) → (2-phenyl-indol-3-yl)-glyoxylic acid piperidide (102318-27-4)

Guidance literature:

With diethyl ether; Behandeln der Reaktionsloesung mit Piperidin;

upstream raw materials:

2-phenyl-indole

oxalyl dichloride

piperidine

2-oxo-(2-phenyl-1H-indol-3-yl)acetyl chloride