2-Ethoxy-5-methoxyaniline

Base Information

• Chemical Name: 2-Ethoxy-5-methoxyaniline
• CAS No.: 102439-33-8
• Molecular Formula: C₉H₁₃NO₂
• Molecular Weight: 167.208
• DSSTox Substance ID: DTXSID80588533
• Wikidata: Q82481255
• Mol file: 102439-33-8.mol

Synonyms:2-ethoxy-5-methoxyaniline;102439-33-8;Benzenamine, 2-ethoxy-5-methoxy-;2-ethoxy-5-methoxy-aniline;SCHEMBL8507803;DTXSID80588533;CEA43933;AKOS000143822;MCULE-5687005416;DB-338372;CS-0258318;EN300-69763;G20274;Z239604774

Chemical Property of 2-Ethoxy-5-methoxyaniline

Chemical Property:

• XLogP3: 1.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 167.094628657
• Heavy Atom Count: 12
• Complexity: 130

Purity/Quality:

98%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC1=C(C=C(C=C1)OC)N

Technology Process of 2-Ethoxy-5-methoxyaniline

There total 4 articles about 2-Ethoxy-5-methoxyaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-ethoxy-4-methoxy-2-nitro-benzene (16169-26-9) → 2-ethoxy-5-methoxy-aniline (102439-33-8)

Guidance literature:

With hydrogenchloride; iron;

Reference yield:

4-methoxy-2-nitrophenol (1568-70-3) → 2-ethoxy-5-methoxy-aniline (102439-33-8)

Guidance literature:

Multi-step reaction with 2 steps

1: ethanol; aqueous NaOH; Na₂CO₃ / 110 °C

2: iron; aq.-ethanolic HCl

With hydrogenchloride; sodium hydroxide; ethanol; iron; sodium carbonate;

Reference yield:

4-methoxy-2-nitroacetanilide (119-81-3) → 2-ethoxy-5-methoxy-aniline (102439-33-8)

Guidance literature:

Multi-step reaction with 3 steps

1: aqueous NaOH

2: aq.-ethanolic NaOH

3: iron; aqueous HCl

With hydrogenchloride; sodium hydroxide; iron;

upstream raw materials:

1-ethoxy-4-methoxy-2-nitro-benzene

4-methoxy-2-nitrophenol

4-methoxy-2-nitroacetanilide