Technology Process of 2-Pyrrolidinone, 3-(2-amino-5-methoxyphenyl)-1,3-dimethyl-
There total 21 articles about 2-Pyrrolidinone, 3-(2-amino-5-methoxyphenyl)-1,3-dimethyl- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydrogen;
palladium on activated charcoal;
In
ethyl acetate;
at 20 ℃;
for 3h;
under 2585.74 Torr;
DOI:10.1021/jo026438u
- Guidance literature:
-
With
aluminium trichloride;
In
dichloromethane; dimethyl sulfoxide;
for 10h;
Ambient temperature;
DOI:10.1021/jo00365a029
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: LDA / heptane; tetrahydrofuran; ethylbenzene / 0.17 h / -78 °C
1.2: 85 percent / heptane; tetrahydrofuran; ethylbenzene / 3 h / -78 - 20 °C
2.1: TASF / tetrahydrofuran; acetonitrile / 15 h / -78 - 20 °C
2.2: 85 percent / DDQ / tetrahydrofuran; acetonitrile / -78 - 20 °C
3.1: 95 percent / nBu4NBr; CsOH*H2O / toluene / 10 h / 20 °C
4.1: 100 percent / H2 / Pd/C / ethyl acetate / 3 h / 20 °C / 2585.74 Torr
With
cesium hydroxide; tetrabutylammomium bromide; tris(dimethylamino)sulfonium trimethylsilyldifluoride; hydrogen; lithium diisopropyl amide;
palladium on activated charcoal;
In
tetrahydrofuran; n-heptane; ethylbenzene; ethyl acetate; toluene; acetonitrile;
DOI:10.1021/jo026438u