Technology Process of 2-Pyrrolidinone, 3-(5-methoxy-2-nitrophenyl)-1,3-dimethyl-
There total 5 articles about 2-Pyrrolidinone, 3-(5-methoxy-2-nitrophenyl)-1,3-dimethyl- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
cesium hydroxide; tetrabutylammomium bromide;
In
toluene;
at 20 ℃;
for 10h;
DOI:10.1021/jo026438u
- Guidance literature:
-
para-methoxynitrobenzene; 1,3-dimethyl-3-trimethylsilanyl-pyrrolidin-2-one;
With
tris(dimethylamino)sulfonium trimethylsilyldifluoride;
In
tetrahydrofuran; acetonitrile;
at -78 - 20 ℃;
for 15h;
With
2,3-dicyano-5,6-dichloro-p-benzoquinone;
In
tetrahydrofuran; acetonitrile;
at -78 - 20 ℃;
DOI:10.1021/jo026438u
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: LDA / heptane; tetrahydrofuran; ethylbenzene / 0.17 h / -78 °C
1.2: 85 percent / heptane; tetrahydrofuran; ethylbenzene / 3 h / -78 - 20 °C
2.1: TASF / tetrahydrofuran; acetonitrile / 15 h / -78 - 20 °C
2.2: 85 percent / DDQ / tetrahydrofuran; acetonitrile / -78 - 20 °C
3.1: 95 percent / nBu4NBr; CsOH*H2O / toluene / 10 h / 20 °C
With
cesium hydroxide; tetrabutylammomium bromide; tris(dimethylamino)sulfonium trimethylsilyldifluoride; lithium diisopropyl amide;
In
tetrahydrofuran; n-heptane; ethylbenzene; toluene; acetonitrile;
DOI:10.1021/jo026438u