2-Butoxypyridine

Base Information

• Chemical Name: 2-Butoxypyridine
• CAS No.: 27361-16-6
• Molecular Formula: C9H13 N O
• Molecular Weight: 151.208
• Hs Code.: 2933399090
• European Community (EC) Number: 248-428-9
• NSC Number: 30253
• DSSTox Substance ID: DTXSID10181793
• Nikkaji Number: J250.500B
• Wikidata: Q72513995
• Mol file: 27361-16-6.mol

Synonyms:2-Butoxypyridine;27361-16-6;2-N-BUTOXYPYRIDINE;Butyl 2-pyridyl ether;EINECS 248-428-9;Pyridine, 2-butoxy-;NSC30253;2-Butoxypyridine, 95%;SCHEMBL6803;2-BUTOXYPYRIDINE, TECH.;DTXSID10181793;CBA36116;MFCD00006267;NSC 30253;NSC-30253;AKOS009031429;SB53791;AS-56769;B1925;CS-0214825;FT-0638696;EN300-19703;D88876;J-016749

Chemical Property of 2-Butoxypyridine

Chemical Property:

• Appearance/Colour: CLEAR LIGHT BEIGE LIQUID
• Vapor Pressure: 0.469mmHg at 25°C
• Refractive Index: n20/D 1.492(lit.)
• Boiling Point: 200°Cat760mmHg
• PKA: 4.13±0.12(Predicted)
• Flash Point: 75°C
• PSA: 22.12000
• Density: 0.968g/cm³
• LogP: 2.26050
• XLogP3: 2.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 4
• Exact Mass: 151.099714038
• Heavy Atom Count: 11
• Complexity: 95.6

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Butoxypyridine ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCCCOC1=CC=CC=N1

Technology Process of 2-Butoxypyridine

There total 20 articles about 2-Butoxypyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

2-bromo-pyridine (109-04-6) + butan-1-ol (71-36-3) → 2-butoxypyridine (27361-16-6)

Guidance literature:

With 5-(di(adamantan-1-yl)phosphino)-1′,3′,5′-triphenyl-1′H-1,4′-bipyrazole; palladium diacetate; caesium carbonate; In toluene; at 80 ℃; for 3h; Inert atmosphere;

DOI:10.1021/ja103248d

Reference yield: 91.0%

2-hydroxypyridin (142-08-5) + 1-iodo-butane (542-69-8) → 2-butoxypyridine (27361-16-6)

Guidance literature:

With silver carbonate; In hexane; at 150 ℃; for 0.166667h; Microwave irradiation;

DOI:10.1055/s-0029-1216878

Reference yield: 89.0%

2-[(but-3-en-1-yl)oxy]pyridine → 2-butoxypyridine (27361-16-6)

Guidance literature:

With iron(III) chloride; lithium aluminium tetrahydride; hydrogen; In tetrahydrofuran; at 18 ℃; for 20h; under 750.075 Torr; Inert atmosphere; Sealed tube;

DOI:10.1039/c4gc02368d

upstream raw materials:

2-chloropyridine

sodium butanolate

pyridine

acetyl hypofluorite

Downstream raw materials:

2-butoxy-5-nitro-pyridine