2-(2-Hydroxyphenyl)-N-methyl-1,3-thiazolidine-3-carboxamide

Base Information

• Chemical Name: 2-(2-Hydroxyphenyl)-N-methyl-1,3-thiazolidine-3-carboxamide
• CAS No.: 103072-75-9
• Molecular Formula: C11H14N2O2S
• Molecular Weight: 238.31
• DSSTox Substance ID: DTXSID00548331
• Mol file: 103072-75-9.mol

Synonyms:103072-75-9;2-(2-Hydroxyphenyl)-N-methyl-1,3-thiazolidine-3-carboxamide;SCHEMBL10367096;DTXSID00548331;LEEIIDFIQAEMHI-UHFFFAOYSA-N;N-methyl-2-(2-hydroxyphenyl)thiazolidine-3-carboxamide

Chemical Property of 2-(2-Hydroxyphenyl)-N-methyl-1,3-thiazolidine-3-carboxamide

Chemical Property:

• XLogP3: 1.2
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 238.07759887
• Heavy Atom Count: 16
• Complexity: 262

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CNC(=O)N1CCSC1C2=CC=CC=C2O

Technology Process of 2-(2-Hydroxyphenyl)-N-methyl-1,3-thiazolidine-3-carboxamide

There total 2 articles about 2-(2-Hydroxyphenyl)-N-methyl-1,3-thiazolidine-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.4%

2-mercaptoethylamine hydrochloride (156-57-0) + salicylaldehyde (90-02-8) + methyl isocyanate (624-83-9) → 2-(2-hydroxyphenyl)-N-methylthiazolidine-3-carboxamide (103072-75-9)

Guidance literature:

With sodium hydroxide; In tetrahydrofuran; ethanol; water; benzene;

Reference yield: 75.0%

salicylaldehyde (90-02-8) + methyl isocyanate (624-83-9) + Cysteamine (60-23-1) → 2-(2-hydroxyphenyl)-N-methylthiazolidine-3-carboxamide (103072-75-9)

Guidance literature:

DOI:10.1248/cpb.35.2394

Reference yield:

2-(2-hydroxyphenyl)-N-methylthiazolidine-3-carboxamide (103072-75-9) + 1-(2-chloroethyl)-4-phenylpiperazine (43219-09-6) → N-methyl-2-{2-[2-(4-phenylpiperazin-1-yl)ethyloxy]phenyl}thiazolidine-3-carboxamide (103072-76-0)

Guidance literature:

With sodium iodide; potassium carbonate; In N-methyl-acetamide; water;

upstream raw materials:

salicylaldehyde

methyl isocyanate

Cysteamine

2-mercaptoethylamine hydrochloride

Downstream raw materials:

N-methyl-2-{2-[2-(4-phenylpiperazin-1-yl)ethyloxy]phenyl}thiazolidine-3-carboxamide

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