3-(2-Hydroxyphenyl)-2-methylprop-2-enoic acid

Base Information

• Chemical Name: 3-(2-Hydroxyphenyl)-2-methylprop-2-enoic acid
• CAS No.: 103487-44-1
• Molecular Formula: C10H10O3
• Molecular Weight: 178.188
• DSSTox Substance ID: DTXSID40710176
• Mol file: 103487-44-1.mol

Synonyms:103487-44-1;3-(2-Hydroxyphenyl)-2-methylprop-2-enoic acid;SCHEMBL208434;DTXSID40710176

Chemical Property of 3-(2-Hydroxyphenyl)-2-methylprop-2-enoic acid

Chemical Property:

• XLogP3: 1.9
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 178.062994177
• Heavy Atom Count: 13
• Complexity: 220

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=CC1=CC=CC=C1O)C(=O)O

Technology Process of 3-(2-Hydroxyphenyl)-2-methylprop-2-enoic acid

There total 3 articles about 3-(2-Hydroxyphenyl)-2-methylprop-2-enoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

ethyl (E)-3-(2-hydroxyphenyl)-2-methylacrylate (112021-87-1) → (E)-3-(2-hydroxyphenyl)-2-methylacrylic acid (103487-44-1)

Guidance literature:

With potassium hydroxide; In ethanol; water; for 0.166667h; Heating;

DOI:10.1021/ja00209a040

Reference yield: 70.0%

methyl-propanedioic acid (516-05-2) + salicylaldehyde (90-02-8) → (E)-3-(2-hydroxyphenyl)-2-methylacrylic acid (103487-44-1)

Guidance literature:

With piperidine; In pyridine; Reflux;

DOI:10.1002/cmdc.201600231

Reference yield:

salicylaldehyde (90-02-8) → (E)-3-(2-hydroxyphenyl)-2-methylacrylic acid (103487-44-1)

Guidance literature:

Multi-step reaction with 2 steps

2: H₂O, base

With water;

DOI:10.1021/ja00238a062

upstream raw materials:

methyl-propanedioic acid

salicylaldehyde

ethyl (E)-3-(2-hydroxyphenyl)-2-methylacrylate

Downstream raw materials:

(E)-3-(2-Hydroxy-phenyl)-2-methyl-acrylic acid 4-carbamimidoyl-phenyl ester