2-Bromo-3-methoxybenzaldehyde

Base Information

• Chemical Name: 2-Bromo-3-methoxybenzaldehyde
• CAS No.: 10401-18-0
• Molecular Formula: C8H7BrO2
• Molecular Weight: 215.046
• Hs Code.: 2913000090
• European Community (EC) Number: 848-466-1
• DSSTox Substance ID: DTXSID50473306
• Nikkaji Number: J756.517H
• Wikidata: Q82302630
• Mol file: 10401-18-0.mol

Synonyms:2-Bromo-3-methoxybenzaldehyde;10401-18-0;MFCD09834663;Benzaldehyde, 2-bromo-3-methoxy-;2-bromo-3-methoxy-benzaldehyde;SCHEMBL137836;DTXSID50473306;KELPUINOQGYPKR-UHFFFAOYSA-N;AKOS022178260;DS-8074;SY257801;CS-0040613;EN300-202528;A896307;Z1269149587

Chemical Property of 2-Bromo-3-methoxybenzaldehyde

Chemical Property:

• Melting Point: 69.5-70 °C(Solv: benzene (71-43-2); ligroine (8032-32-4))
• Boiling Point: 277.6±20.0 °C(Predicted)
• PSA: 26.30000
• Density: 1.522±0.06 g/cm3(Predicted)
• LogP: 2.27020
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• XLogP3: 1.9
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 213.96294
• Heavy Atom Count: 11
• Complexity: 138

Purity/Quality:

97% ^*data from raw suppliers

2-Bromo-3-methoxybenzaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=CC(=C1Br)C=O

Technology Process of 2-Bromo-3-methoxybenzaldehyde

There total 7 articles about 2-Bromo-3-methoxybenzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-bromo-3-hydroxy-benzaldehyde (196081-71-7) + methyl iodide (74-88-4) → 2-bromo-3-methoxybenzaldehyde (10401-18-0)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 16h;

Reference yield: 96.0%

3-methoxy-benzaldehyde (591-31-1) → 2-bromo-3-methoxybenzaldehyde (10401-18-0)

Guidance literature:

3-methoxy-benzaldehyde; With n-butyllithium; N,N',N'-trimethylenediamine; In hexane; toluene; at 20 ℃; for 0.25h;

With phenyllithium; In various solvents; at 20 ℃; for 8h;

With 1,2-dibromo-1,1,2,2-tetrafluoroethane; In various solvents; at -78 - 20 ℃; Further stages.;

DOI:10.1016/j.tet.2004.01.095

Reference yield: 94.0%

(2-bromo-3-methoxyphenyl)methanol (199436-55-0) → 2-bromo-3-methoxybenzaldehyde (10401-18-0)

Guidance literature:

With pyridinium chlorochromate; In dichloromethane; at 24 ℃; Inert atmosphere;

DOI:10.1002/anie.201003549

upstream raw materials:

2-bromo-3-methylanisole

3-methoxy-benzaldehyde

(2-bromo-3-methoxyphenyl)methanol

2-bromo-3-hydroxy-benzaldehyde

Downstream raw materials:

2-bromo-3-methoxybenzoic acid

(2-bromo-3-methoxyphenyl)methanol

1-Hydroxy-1-(2-brom-3-methoxy-phenyl)-hexa-2,4-diin

2-bromo-3-methoxybenzoyl chloride