2-Bromo-3-methoxybenzyl alcohol

Base Information

• Chemical Name: 2-Bromo-3-methoxybenzyl alcohol
• CAS No.: 199436-55-0
• Molecular Formula: C8H9BrO2
• Molecular Weight: 217.062
• Hs Code.: 2909498090
• European Community (EC) Number: 816-271-0
• Nikkaji Number: J1.309.260E
• Mol file: 199436-55-0.mol

Synonyms:2-Bromo-3-methoxybenzyl alcohol;199436-55-0;(2-Bromo-3-methoxyphenyl)methanol;Benzenemethanol, 2-bromo-3-methoxy-;SCHEMBL7674886;ZHA43655;MFCD18391884;AKOS024087440;PS-11760;CS-0194438;E82310

Chemical Property of 2-Bromo-3-methoxybenzyl alcohol

Chemical Property:

• PSA: 29.46000
• LogP: 1.95000
• XLogP3: 1.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 215.97859
• Heavy Atom Count: 11
• Complexity: 119

Purity/Quality:

95% ^*data from raw suppliers

2-Bromo-3-methoxybenzylAlcohol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=CC(=C1Br)CO

Technology Process of 2-Bromo-3-methoxybenzyl alcohol

There total 5 articles about 2-Bromo-3-methoxybenzyl alcohol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

2-bromo-3-methoxybenzoic acid (88377-29-1) → (2-bromo-3-methoxyphenyl)methanol (199436-55-0)

Guidance literature:

With borane-THF; In tetrahydrofuran; at 0 - 24 ℃; Inert atmosphere;

DOI:10.1002/anie.201003549

Reference yield: 85.0%

3-methoxybenzyl alcohol (6971-51-3) → (2-bromo-3-methoxyphenyl)methanol (199436-55-0)

Guidance literature:

3-methoxybenzyl alcohol; With n-butyllithium; In hexane; toluene; at -40 - 20 ℃; for 4h;

With 1,2-dibromo-1,1,2,2-tetrafluoroethane; In tetrahydrofuran; hexane; toluene; at -40 - 20 ℃;

DOI:10.1002/chem.201003166

Reference yield: 28.0%

3-methoxybenzyl alcohol (6971-51-3) → (4-bromo-3-methoxyphenyl)methanol (17100-64-0) + (2-bromo-3-methoxyphenyl)methanol (199436-55-0)

Guidance literature:

With n-butyllithium; 1,2-dibromo-1,1,2,2-tetrafluoroethane; potassium tert-butylate; In tetrahydrofuran; hexane; -78 deg C; -78 deg C, 4.5 h; -78 deg C, 10 min;

DOI:10.1071/C97016

upstream raw materials:

2-bromo-3-methoxybenzaldehyde

3-methoxybenzyl alcohol

3-methoxy-benzaldehyde

2-bromo-3-methoxybenzoic acid

Downstream raw materials:

1-bromo-2-methoxy-6-(methoxymethyl)benzene

2-bromo-3-methoxybenzaldehyde

2-bromo-1-(bromomethyl)-3-methoxybenzene

1-(2'-bromo-3'-methoxybenzyl) 2-tert-butyl 3-methoxy-9,10-anthraquinone-1,2-dicarboxylate