Benzenemethanol, 6-(dimethoxymethyl)-a-(3,4-dimethoxyphenyl)-2,3,4-trimethoxy-

Base Information

• Chemical Name: Benzenemethanol, 6-(dimethoxymethyl)-a-(3,4-dimethoxyphenyl)-2,3,4-trimethoxy-
• CAS No.: 104756-71-0
• Molecular Formula: C21H28O8
• Molecular Weight: 408.449
• Mol file: 104756-71-0.mol

Synonyms:(6-Dimethoxymethyl-2,3,4-trimethoxy-phenyl)-(3,4-dimethoxy-phenyl)-methanol;2-(3,4-dimethoxy-α-hydroxybenzyl)-3,4,5-trimethoxybenzaldehyde dimethyl acetal;2-(α-hydroxy-3,4-dimethoxybenzyl)-3,4,5-trimethoxybenzaldehyde dimethylacetal;

Chemical Property of Benzenemethanol, 6-(dimethoxymethyl)-a-(3,4-dimethoxyphenyl)-2,3,4-trimethoxy-

Chemical Property:

• PSA: 84.84000
• LogP: 3.10270

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzenemethanol, 6-(dimethoxymethyl)-a-(3,4-dimethoxyphenyl)-2,3,4-trimethoxy-

There total 2 articles about Benzenemethanol, 6-(dimethoxymethyl)-a-(3,4-dimethoxyphenyl)-2,3,4-trimethoxy- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3,4-dimethoxy-benzaldehyde (120-14-9) + 2-bromo-3,4,5-trimethoxybenzaldehydedimethyl acetal (87850-44-0) → 2-(3,4-dimethoxy-α-hydroxybenzyl)-3,4,5-trimethoxybenzaldehyde dimethylacetal (104756-71-0)

Guidance literature:

With n-butyllithium; Multistep reaction; 1.) hexane, THF, -70 deg C, 15 min, 2.) hexane, THF, -70 deg C, 15 min;

DOI:10.1248/cpb.43.1701

Reference yield:

3,4,5-trimethoxybenzaldehyde dimethyl acetal (59276-37-8) + 3,4-dimethoxy-benzaldehyde (120-14-9) → 2-(3,4-dimethoxy-α-hydroxybenzyl)-3,4,5-trimethoxybenzaldehyde dimethylacetal (104756-71-0)

Guidance literature:

With n-butyllithium; In tetrahydrofuran; hexane; water; ethyl acetate;

Reference yield: 83.0%

dimethyl acetylenedicarboxylate (762-42-5) + 2-(3,4-dimethoxy-α-hydroxybenzyl)-3,4,5-trimethoxybenzaldehyde dimethylacetal (104756-71-0) → 2,3-bis(methoxycarbonyl)-1-(3,4-dimethoxyphenyl)-4-hydroxy-6,7,8-trimethoxynaphthalene (104756-72-1)

Guidance literature:

With toluene-4-sulfonic acid; In benzene; for 2h; Heating;

DOI:10.1248/cpb.43.1701

upstream raw materials:

3,4-dimethoxy-benzaldehyde

2-bromo-3,4,5-trimethoxybenzaldehydedimethyl acetal

3,4,5-trimethoxybenzaldehyde dimethyl acetal

Downstream raw materials:

2,3-bis(methoxycarbonyl)-1-(3,4-dimethoxyphenyl)-4-hydroxy-6,7,8-trimethoxynaphthalene

1-(3,4-dimethoxyphenyl)-2,3-bis(ethoxycarbonyl)-4-hydroxy-6,7,8-trimethoxynaphthalene

2-(α-methoxy-3,4-dimethoxybenzyl)-3,4,5-trimethoxybenzaldehyde dimethylacetal

2-(α-acetoxy-3,4-dimethoxybenzyl)-3,4,5-trimethoxybenzaldehyde dimethylacetal