59276-37-8

Basic information

• Product Name: 3,4,5-TRIMETHOXYBENZALDEHYDE DIMETHYL ACETAL
• Synonyms: 3,4,5-TRIMETHOXYBENZALDEHYDE DIMETHYL ACETAL;1,2,3-Trimethoxy-5-(dimethoxymethyl)benzene
• CAS NO: 59276-37-8
• Molecular Formula: C₁₂H₁₈O₅
• Molecular Weight: 242.27
• Product Categories: Acetals/Ketals/Ortho Esters;Organic Building Blocks;Oxygen Compounds
• Mol File: 59276-37-8.mol
• Article Data: 15

Chemical Properties

• Boiling Point: 180 °C10 mm Hg(lit.)
• Flash Point: >230 °F
• Appearance: /
• Density: 1.147 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.00324mmHg at 25°C
• Refractive Index: n20/D 1.514(lit.)
• CAS DataBase Reference: 3,4,5-TRIMETHOXYBENZALDEHYDE DIMETHYL ACETAL(CAS DataBase Reference)
• NIST Chemistry Reference: 3,4,5-TRIMETHOXYBENZALDEHYDE DIMETHYL ACETAL(59276-37-8)
• EPA Substance Registry System: 3,4,5-TRIMETHOXYBENZALDEHYDE DIMETHYL ACETAL(59276-37-8)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 59276-37-8(Hazardous Substances Data)

Usage

General Description

3,4,5-Trimethoxybenzaldehyde dimethyl acetal is a chemical compound used in various industries. It is a colorless liquid with a fruity odor and is primarily used as a flavoring agent in the food and beverage industry. It is also utilized as an intermediate in the synthesis of pharmaceuticals and agrochemicals. Additionally, 3,4,5-Trimethoxybenzaldehyde dimethyl acetal is found in some cosmetic and personal care products. Due to its versatile properties, this chemical compound is a valuable ingredient in the production of a wide range of consumer goods.

InChI:InChI=1/C12H18O5/c1-13-9-6-8(12(16-4)17-5)7-10(14-2)11(9)15-3/h6-7,12H,1-5H3

Upstream product

• 67-56-1 methanol 
• 86-81-7 3,4,5-trimethoxy-benzaldehyde 
• 149-73-5 trimethyl orthoformate 

Downstream Products

• 140464-70-6 3,5-dimethoxy-1-(1,3-dioxolan-2-yl)benzene 
• 140464-77-3 1-(4-Dimethoxymethyl-2,6-dimethoxy-phenyl)-2,2-dimethyl-propan-1-ol 
• 57009-70-8 2-(3,4,5-trimethoxyphenyl)-1,3-dithiane 
• 30225-78-6 (3,4,5-Trimethoxyphenyl)methylene diacetate 
• 566934-92-7 5-dimethoxymethyl-2-isopropenyl-1,3-dimethoxy-benzene 
• 344396-19-6 3,5-dimethoxy-4-(1-methylethyl)benzaldehyde 
• 69194-92-9 3,5-dimethoxy-4-(methylethenyl)benzaldehyde 
• 141509-20-8 (E)-1,3-dimethoxy-2-(1-methylethyl)-5-(2-phenylethenyl)benzene 
• 141509-19-5 (E)-2-ethyl-1,3-dimethoxy-5-(2-phenylethenyl)benzene 
• 78025-99-7 3,5-dimethoxy-4-ethylbenzaldehyde 
• 862847-68-5 ethyl (R)-3-butyl-2,4-dimethoxy-6-(2-methoxyheptyl)benzoate 
• 862847-67-4 (R)-2-bromo-4-butyl-3,5-dimethoxy-1-(2-methoxyheptyl)benzene 
• 862847-64-1 (1R,2R)-1-(4-butyl-3,5-dimethoxyphenyl)heptane-1,2-diol 
• 862847-66-3 (R)-2-butyl-1,3-dimethoxy-5-(2-methoxyheptyl)benzene 

Relevant articles and documents

Tropylium salts as efficient organic Lewis acid catalysts for acetalization and transacetalization reactions in batch and flow

Acetalization reactions play significant roles in the synthetically important masking chemistry of carbonyl compounds. Herein we demonstrate for the first time that tropylium salts can act as organic Lewis acid catalysts to facilitate acetalization and transacetalization reactions of a wide range of aldehyde substrates. This metal-free method works efficiently in both batch and flow conditions, prompting further future applications of tropylium organocatalysts in green synthesis.

Diterpenoid alkaloid lappaconine derivative catalyzed asymmetric α-hydroxylation of β-dicarbonyl compounds with hydrogen peroxide

A new framework derived from the commercially available diterpenoid alkaloid lappaconitine was evaluated as a Bronsted base catalyst for the enantioselective α-hydroxylation of β-dicarbonyl compounds by using 30% hydrogen peroxide as a green and highly practical source of oxygen. This protocol allows convenient access to the corresponding α-hydroxy-β- oxo esters, α-hydroxy-β-oxo amides and (-)-kjellmanianone with up to 98% yield and 92% ee. Copyright

New two-step sequence involving a hetero-Diels-Alder and a nonphenolic oxidative coupling reaction: A convergent access to analogs of steganacin

A new family of analogs of steganacin, an important antimitotic compound, was accessed. It takes advantage of a completely stereoselective sequence of two key steps. The central dihydropyrane core is built by a highly diastereoselective and facially controlled hetero-Diels-Alder reaction. It is followed by a nonphenolic biaryl oxidative coupling with a complete atropo-stereoselectivity. It leads to a quick way to form cyclic biaryl lignans.