2,2,4,5-Tetraphenyl-2,3-dihydrofuran

Base Information

• Chemical Name: 2,2,4,5-Tetraphenyl-2,3-dihydrofuran
• CAS No.: 1056-32-2
• Molecular Formula: C28H22O
• Molecular Weight: 374.482
• DSSTox Substance ID: DTXSID70550002
• Wikidata: Q82429210
• Mol file: 1056-32-2.mol

Synonyms:2,2,4,5-Tetraphenyl-2,3-dihydrofuran;1056-32-2;DTXSID70550002;2,3-dihydro-2,2,4,5-tetraphenylfuran

Chemical Property of 2,2,4,5-Tetraphenyl-2,3-dihydrofuran

Chemical Property:

• XLogP3: 6.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 4
• Exact Mass: 374.167065321
• Heavy Atom Count: 29
• Complexity: 533

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1C(=C(OC1(C2=CC=CC=C2)C3=CC=CC=C3)C4=CC=CC=C4)C5=CC=CC=C5

Technology Process of 2,2,4,5-Tetraphenyl-2,3-dihydrofuran

There total 2 articles about 2,2,4,5-Tetraphenyl-2,3-dihydrofuran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

phenyl benzyl ketone (451-40-1) + 1,1-Diphenylethylene (530-48-3) → 2,2,4,5-tetraphenyl-2,3-dihydrofuran (1056-32-2)

Guidance literature:

With copper(II) bis(trifluoromethanesulfonate); In N,N-dimethyl-formamide; at 120 ℃; for 16h; regioselective reaction;

DOI:10.1021/acs.joc.7b00476

Reference yield: 80.0%

1,1-Diphenylethylene (530-48-3) + 1,1-Dibromdesoxybenzoin (15023-99-1) → 2,2,4,5-tetraphenyl-2,3-dihydrofuran (1056-32-2)

Guidance literature:

With samarium diiodide; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; for 2h; Heating;

DOI:10.1039/c39870000919

Reference yield:

2,2,4,5-tetraphenyl-2,3-dihydrofuran (1056-32-2) → (1,2-diphenylcyclopropyl)benzene (896-65-1)

Guidance literature:

Multi-step reaction with 2 steps

1: benzene / Irradiation

2: KOtBu

With potassium tert-butylate; In benzene;

DOI:10.1021/ja01076a092

upstream raw materials:

1,1-Diphenylethylene

1,1-Dibromdesoxybenzoin

phenyl benzyl ketone

Downstream raw materials:

1-Benzoyl-1,2,2-triphenyl-cyclopropan

(1,2-diphenylcyclopropyl)benzene