Isosalvianolic acid C

Base Information

• Chemical Name: Isosalvianolic acid C
• CAS No.: 142115-17-1
• Molecular Formula: C26H20 O10
• Molecular Weight: 492.439
• Mol file: 142115-17-1.mol

Synonyms:Benzenepropanoicacid, 3,4-dihydroxy-a-[[(2E)-1-oxo-3-(4,7,8-trihydroxydibenz[b,f]oxepin-1-yl)-2-propenyl]oxy]-,(aR)- (9CI); Benzenepropanoic acid,3,4-dihydroxy-a-[[1-oxo-3-(4,7,8-trihydroxydibenz[b,f]oxepin-1-yl)-2-propenyl]oxy]-,[R-(E)]-; Dibenz[b,f]oxepin, benzenepropanoic acid deriv.; Isosalvianolic acidC

Chemical Property of Isosalvianolic acid C

Chemical Property:

• PSA: 173.98000
• LogP: 3.74300

Purity/Quality:

99%, ^*data from raw suppliers

IsosalvianolicacidC ≥98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Isosalvianolic acid C

There total 2 articles about Isosalvianolic acid C which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

lithospermic acid → danshensu (23028-17-3,42085-50-7,69339-96-4,76822-21-4) + Isosalvianolic acid C (142115-17-1) + (2S,3S)-4-[(E)-2-carboxyethenyl]-2-(3,4-dihydroxyphenyl)-2,3-dihydro-7-hydroxy-3-benzofurancarboxylic acid (136112-75-9) + (2R)-3-(3,4-dihydroxyphenyl)-2-[(E)-3-[2-(3,4-dihydroxyphenyl)-7-hydroxy-1-benzofuran-4-yl]prop-2-enoyl]oxypropanoic acid + salvianolic acid A

Guidance literature:

In aq. phosphate buffer; water-d2; at 100 ℃; pH=4.75; Kinetics; Sealed tube; Inert atmosphere;

DOI:10.1371/journal.pone.0164421

Reference yield:

salvianolic acid A → C26H22O11 (1338058-98-2) + C26H22O11 (1338058-99-3) + C26H22O11 (1338059-01-0) + C26H22O11 (1338059-00-9) + Isosalvianolic acid C (142115-17-1) + (2R)-3-(3,4-dihydroxyphenyl)-2-[(E)-3-[2-(3,4-dihydroxyphenyl)-7-hydroxy-1-benzofuran-4-yl]prop-2-enoyl]oxypropanoic acid

Guidance literature:

In water; at 90 ℃;

DOI:10.1016/j.fitote.2010.10.008

Reference yield:

Isosalvianolic acid C (142115-17-1) + dimethyl sulfate (77-78-1) → (E)-3-(4,7,8-Trimethoxy-dibenzo[b,f]oxepin-1-yl)-acrylic acid (R)-2-(3,4-dimethoxy-phenyl)-1-methoxycarbonyl-ethyl ester (141808-79-9)

Guidance literature:

With potassium carbonate; In acetone; for 32h;

DOI:10.1016/0031-9422(92)80081-O

Downstream raw materials:

(E)-3-(4,7,8-Trimethoxy-dibenzo[b,f]oxepin-1-yl)-acrylic acid (R)-2-(3,4-dimethoxy-phenyl)-1-methoxycarbonyl-ethyl ester