2-Amino-4-hydroxypentanedioic acid

Base Information

• Chemical Name: 2-Amino-4-hydroxypentanedioic acid
• CAS No.: 533-62-0
• Molecular Formula: C₅H₉NO₅
• Molecular Weight: 163.13
• NSC Number: 206309,206306
• DSSTox Substance ID: DTXSID80274287,DTXSID20863114
• Nikkaji Number: J2.366.731B
• Wikidata: Q82003662
• Mol file: 533-62-0.mol

Synonyms:H-(2S,4S)-Gamma-Hydroxy-Glu-OH;UNII-MB5HCK64QF;(4R)-4-Hydroxy-L-glutamic acid;EINECS 208-572-5;H-(2S,4R)-Gamma-Hydroxy-Glu-OH;2-amino-4-hydroxypentanedioic acid;(2S,4R)-4-Hydroxy-L-glutamic Acid;3157-41-3;MB5HCK64QF;4-hydroxy-dl-glutamic acid;(2S,4R)-2-ammonio-4-hydroxypentanedioate;SCHEMBL305904;DTXSID20863114;DTXSID80274287;NSC206306;NSC206309;NSC-206306;NSC-206309;erythro-4-Hydroxy-L-glutamic acid(1-);PD197624;FT-0669646;FT-0669647;(2S,4R)-2-ammonio-4-Hydroxypentanedioic acid;2-Amino-4-hydroxypentanedioic acid (non-preferred name);56614-13-2

Chemical Property of 2-Amino-4-hydroxypentanedioic acid

Chemical Property:

• Vapor Pressure: 1.33E-09mmHg at 25°C
• Melting Point: 283 °C
• Refractive Index: 1.565
• Boiling Point: 440.3 °C at 760 mmHg
• PKA: 2.02±0.10(Predicted)
• Flash Point: 220.1 °C
• PSA: 120.85000
• Density: 1.595 g/cm³
• LogP: -1.06580
• XLogP3: -4.1
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 4
• Exact Mass: 163.04807239
• Heavy Atom Count: 11
• Complexity: 168

Purity/Quality:

99%, ^*data from raw suppliers

3-HYDROXYGLUTAMIC ACID 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C(C(C(=O)O)N)C(C(=O)O)O

Technology Process of 2-Amino-4-hydroxypentanedioic acid

There total 23 articles about 2-Amino-4-hydroxypentanedioic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-(2,5-dioxo-imidazolidin-4-yl)-acrylic acid (98197-90-1) → 2-amino-3-hydroxypentanedioic acid (533-62-0,17598-55-9,25541-20-2)

Guidance literature:

Reference yield:

hydrogenchloride (7647-01-0,15364-23-5) + 3-bromo-3-(2,5-dioxo-imidazolidin-4-yl)-propionic acid → 2-amino-3-hydroxypentanedioic acid (533-62-0,17598-55-9,25541-20-2)

Guidance literature:

anschliessend Kochen des Reaktionsprodukts mit Kalkmilch;

Reference yield:

3-bromo-3-(2,5-dioxo-imidazolidin-4-yl)-propionic acid + hydrogen bromide (10035-10-6,12258-64-9) → 2-amino-3-hydroxypentanedioic acid (533-62-0,17598-55-9,25541-20-2)

Guidance literature:

anschliessend Kochen des Reaktionsprodukts mit Kalkmilch;

upstream raw materials:

hydrogenchloride

hydrogen bromide

3-(2,5-dioxo-imidazolidin-4-yl)-acrylic acid

ethanol

Downstream raw materials:

betaine

α-ketoglutaric acid

ammonia

2-{4-[2-(2,4-Diamino-pteridin-6-yl)-ethyl]-benzoylamino}-3-hydroxy-pentanedioic acid

Refernces

• 1、 Vidal-Cros, Anne,Gaudry, Michel,Marquet, Andree. "L-threo- and L-erythro-3-Fluoroglutamic Acids. Synthesis by Fluorodehydroxylation and Enzymatic Resolution.". . p. 3163 - 3167. Retrieved 2007/10/02.