Diethyl (2,4-dichloro-5-fluoro-3-nitrobenzoyl)propanedioate

Base Information

Chemical Name:Diethyl (2,4-dichloro-5-fluoro-3-nitrobenzoyl)propanedioate
CAS No.:106809-16-9
Molecular Formula:C14H12Cl2FNO7
Molecular Weight:396.156
Hs Code.:
DSSTox Substance ID:DTXSID10547911
Wikidata:Q82426443
Mol file:106809-16-9.mol

Synonyms:106809-16-9;SCHEMBL9671784;DTXSID10547911;UMCIIIXCSXZJNZ-UHFFFAOYSA-N;Diethyl (2,4-dichloro-5-fluoro-3-nitrobenzoyl)propanedioate;diethyl(2,4-dichloro-5-fluoro-3-nitrobenzoyl)malonate;diethyl (2,4-dichloro-5-fluoro-3-nitrobenzoyl)malonate;diethyl(2,4-dichloro- 5-fluoro-3-nitro-benzoyl)malonate;diethyl (2,4 -dichloro-5-fluoro-3-nitro-benzoyl)malonate;diethyl (2,4-dichloro-5-fluoro-3-nitro-benzoyl)-malonate

Suppliers and Price of Diethyl (2,4-dichloro-5-fluoro-3-nitrobenzoyl)propanedioate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemical Property of Diethyl (2,4-dichloro-5-fluoro-3-nitrobenzoyl)propanedioate

Chemical Property:

XLogP3:3.7
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:8
Exact Mass:394.9974853
Heavy Atom Count:25
Complexity:524

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CCOC(=O)C(C(=O)C1=CC(=C(C(=C1Cl)[N+](=O)[O-])Cl)F)C(=O)OCC

Technology Process of Diethyl (2,4-dichloro-5-fluoro-3-nitrobenzoyl)propanedioate

There total 4 articles about Diethyl (2,4-dichloro-5-fluoro-3-nitrobenzoyl)propanedioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 7664-93-9
sulfuric acid

: 104600-29-5
2,4-dichloro-5-fluoro-3-nitro-benzoyl chloride

: 105-53-3
diethyl malonate

: 106809-16-9
diethyl (2,4-dichloro-5-fluoro-3-nitro-benzoyl)-malonate

Guidance literature:: With magnesium; In tetrachloromethane; ethanol; water; toluene;

Reference yield:

: 104600-29-5
2,4-dichloro-5-fluoro-3-nitro-benzoyl chloride

: 105-53-3
diethyl malonate

: 106809-16-9
diethyl (2,4-dichloro-5-fluoro-3-nitro-benzoyl)-malonate

Guidance literature:: diethyl malonate; With tetrachloromethane; ethanol; magnesium; In toluene; at 70 ℃; for 2h;

2,4-dichloro-5-fluoro-3-nitro-benzoyl chloride; In toluene; at 0 - 20 ℃;

With sulfuric acid; at 0 ℃;
DOI:10.1128/aac.42.5.1151

Reference yield:

: 106809-14-7
2,4-dichloro-5-fluoro-3-nitro-benzoic acid

: 106809-16-9
diethyl (2,4-dichloro-5-fluoro-3-nitro-benzoyl)-malonate

Guidance literature:: Multi-step reaction with 2 steps

1.1: 91 percent / thionylchloride / 1 h / Heating

2.1: Mg; ethanol; tetrachloromethane / toluene / 2 h / 70 °C

2.2: toluene / 0 - 20 °C

2.3: aq. sulfuric acid / 0 °C

With tetrachloromethane; thionyl chloride; ethanol; magnesium; In toluene;
DOI:10.1128/aac.42.5.1151