4-ACETAMIDO-3-NITROACETOPHENONE

Base Information

• Chemical Name: 4-ACETAMIDO-3-NITROACETOPHENONE
• CAS No.: 7418-44-2
• Molecular Formula: C10H10N2O4
• Molecular Weight: 222.2
• Mol file: 7418-44-2.mol

Synonyms:3-nitro-4-acetamidoacetophenone;N-Acetyl-3-methyl-pyrrolo<1,2-a>piperazin;N-acetyl-3-nitro-4-aminoacetophenone;

Chemical Property of 4-ACETAMIDO-3-NITROACETOPHENONE

Chemical Property:

• Vapor Pressure: 3.57E-07mmHg at 25°C
• Melting Point: 139 °C(Solv: ethanol (64-17-5))
• Boiling Point: 417.3°C at 760 mmHg
• PKA: 13.30±0.70(Predicted)
• Flash Point: 206.2°C
• PSA: 91.99000
• Density: 1.339g/cm³
• LogP: 2.35200

Purity/Quality:

95% ^*data from raw suppliers

4-ACETAMIDO-3-NITROACETOPHENONE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-ACETAMIDO-3-NITROACETOPHENONE

There total 6 articles about 4-ACETAMIDO-3-NITROACETOPHENONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

acetic anhydride (108-24-7) + p-aminobenzophenone (99-92-3) → 1-(4-acetylamino-3-nitrophenyl)ethanone (7418-44-2)

Guidance literature:

With bismuth (III) nitrate pentahydrate; In dichloromethane; at 23 ℃; regioselective reaction;

DOI:10.1016/j.tet.2013.08.076

Reference yield: 70.0%

acetic acid-(4-ethyl-2-nitro-anilide) (3663-33-0) → 1-(4-acetylamino-3-nitrophenyl)ethanone (7418-44-2)

Guidance literature:

With hydrogen bromide; dihydrogen peroxide; In dichloromethane; water; at 20 ℃; for 15h;

DOI:10.1016/j.tetlet.2007.01.172

Reference yield:

N-acetyl-N-phenylacetamide (1563-87-7) → 1-(4-acetylamino-3-nitrophenyl)ethanone (7418-44-2)

Guidance literature:

With nitric acid; acetic anhydride; In (2S)-N-methyl-1-phenylpropan-2-amine hydrate;

upstream raw materials:

1-(4-amino-3-nitrophenyl)ethanone

acetic acid-(4-ethyl-2-nitro-anilide)

N-acetyl-N-phenylacetamide

p-aminobenzophenone

Downstream raw materials:

2-(4-acetylamino-3-nitro-phenyl)-6-nitro-quinoline-4-carboxylic acid

1-(4-amino-3-nitrophenyl)ethanone

(E)-1-(4-Amino-3-nitro-phenyl)-3-furan-2-yl-propenone

(E)-1,3-Bis-(4-amino-3-nitro-phenyl)-propenone