1-Benzothiepin-2-carboxylic acid, 2,3,4,5-tetrahydro-3-hydroxy-2-[3-(4-phenyl-1-piperazinyl)propyl]-, methyl ester, cis-

Base Information

Chemical Name:1-Benzothiepin-2-carboxylic acid, 2,3,4,5-tetrahydro-3-hydroxy-2-[3-(4-phenyl-1-piperazinyl)propyl]-, methyl ester, cis-
CAS No.:108495-68-7
Molecular Formula:C₂₅H₃₂N₂O₃S
Molecular Weight:440.607
Hs Code.:
Mol file:108495-68-7.mol

Synonyms:

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Chemical Property of 1-Benzothiepin-2-carboxylic acid, 2,3,4,5-tetrahydro-3-hydroxy-2-[3-(4-phenyl-1-piperazinyl)propyl]-, methyl ester, cis-

Chemical Property:

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Technology Process of 1-Benzothiepin-2-carboxylic acid, 2,3,4,5-tetrahydro-3-hydroxy-2-[3-(4-phenyl-1-piperazinyl)propyl]-, methyl ester, cis-

There total 4 articles about 1-Benzothiepin-2-carboxylic acid, 2,3,4,5-tetrahydro-3-hydroxy-2-[3-(4-phenyl-1-piperazinyl)propyl]-, methyl ester, cis- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 92-54-6
4-phenyl-1-piperazine

: 108495-56-3
methyl cis-2-(3-chloropropyl)-3-hydroxy-2,3,4,5-tetrahydro-1-benzothiepin-2-carboxylate

: 108495-68-7,108522-69-6
methyl cis-3-hydroxy-2-<3-(4-phenyl-1-piperazinyl)propyl>-2,3,4,5-tetrahydro-1-benzotiepin-2-carboxylate

Guidance literature:: With potassium iodide; at 90 ℃; for 3h;
DOI:10.1248/cpb.35.1930

Reference yield:

: 108495-54-1
methyl 3-oxo-2,3,4,5-tetrahydro-1-benzothiepin-2-carboxylate

: 108495-68-7,108522-69-6
methyl cis-3-hydroxy-2-<3-(4-phenyl-1-piperazinyl)propyl>-2,3,4,5-tetrahydro-1-benzotiepin-2-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 41 percent / K₂CO₃/KI / acetonitrile / 3 h / Heating

2: 80 percent / NaBH₄

3: 60 percent / KI / 3 h / 90 °C

With sodium tetrahydroborate; potassium carbonate; potassium iodide; In acetonitrile;
DOI:10.1248/cpb.35.1930

Reference yield:

: 108495-53-0
methyl 3-(2-methoxycarbonylmethylthiophenyl)propionate

: 108495-68-7,108522-69-6
methyl cis-3-hydroxy-2-<3-(4-phenyl-1-piperazinyl)propyl>-2,3,4,5-tetrahydro-1-benzotiepin-2-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: 81 percent / 60percent NaH / 2-methyl-propan-2-ol; toluene / 0.5 h / Heating

2: 41 percent / K₂CO₃/KI / acetonitrile / 3 h / Heating

3: 80 percent / NaBH₄

4: 60 percent / KI / 3 h / 90 °C

With sodium tetrahydroborate; sodium hydride; potassium carbonate; potassium iodide; In toluene; acetonitrile; tert-butyl alcohol;
DOI:10.1248/cpb.35.1930