6H-Pyrido[4,3-b]carbazole, 9-methoxy-5,6,11-trimethyl-

Base Information

• Chemical Name: 6H-Pyrido[4,3-b]carbazole, 9-methoxy-5,6,11-trimethyl-
• CAS No.: 18073-32-0
• Molecular Formula: C₁₉H₁₈N₂O
• Molecular Weight: 290.365
• NSC Number: 109442
• UNII: YP1DWP84HF
• DSSTox Substance ID: DTXSID60171003
• Wikidata: Q83041033
• ChEMBL ID: CHEMBL304910
• Mol file: 18073-32-0.mol

Synonyms:18073-32-0;9-methoxy-5,6,11-trimethylpyrido[4,3-b]carbazole;YP1DWP84HF;N-Methyl-9-methoxyellipticine;6H-pyrido[4,3-b]carbazole,9-methoxy-5,6,11-trimethyl-;6H-Pyrido[4,3-b]carbazole, 9-methoxy-5,6,11-trimethyl-;NSC-109442;6H-Pyrido(4,3-b)carbazole, 9-methoxy-5,6,11-trimethyl-;9-Methoxy-5,6,11-trimethyl-6H-pyrido[4,3-b]carbazole;9-METHOXY-5,6,11-TRIMETHYL-6H-PYRIDO(4,3-B)CARBAZOLE;NSC109442;NSC 109442;UNII-YP1DWP84HF;CHEMBL304910;SCHEMBL11835361;DTXSID60171003;IHAQVTYZXHXYAL-UHFFFAOYSA-N;6-METHYL-9-METHOXYELLIPTICINE;9-METHOXY-6-METHYLELLIPTICINE;6H-Pyrido(4,3-b)carbazole, 9-methoxy-5,6,11-trimethyl- (8CI)(9CI);6H-Pyrido[4, 9-methoxy-5,6,11-trimethyl-

Chemical Property of 6H-Pyrido[4,3-b]carbazole, 9-methoxy-5,6,11-trimethyl-

Chemical Property:

• Vapor Pressure: 1.68E-10mmHg at 25°C
• Boiling Point: 509.5°Cat760mmHg
• Flash Point: 261.9°C
• PSA: 27.05000
• Density: 1.19g/cm³
• LogP: 4.50510
• XLogP3: 4.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 290.141913202
• Heavy Atom Count: 22
• Complexity: 414

Purity/Quality:

85.0-99.8% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=C2C=CN=CC2=C(C3=C1N(C4=C3C=C(C=C4)OC)C)C

Technology Process of 6H-Pyrido[4,3-b]carbazole, 9-methoxy-5,6,11-trimethyl-

There total 7 articles about 6H-Pyrido[4,3-b]carbazole, 9-methoxy-5,6,11-trimethyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

9-methoxyellipticine (10371-86-5) + methyl iodide (74-88-4) → 9-Methoxy-5,6,11-trimethyl-6H-pyrido<4,3-b>carbazol (18073-32-0)

Guidance literature:

9-methoxyellipticine; With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃; for 0.5h;

methyl iodide; In N,N-dimethyl-formamide; at 0 - 20 ℃;

DOI:10.1016/j.bmc.2011.07.020

Reference yield:

9-methoxyellipticine (10371-86-5) + water (7732-18-5) + methyl iodide (74-88-4) → 9-Methoxy-5,6,11-trimethyl-6H-pyrido<4,3-b>carbazol (18073-32-0)

Guidance literature:

In N-methyl-acetamide;

Reference yield:

5-methoxylindole (1006-94-6) → 9-Methoxy-5,6,11-trimethyl-6H-pyrido<4,3-b>carbazol (18073-32-0)

Guidance literature:

Multi-step reaction with 5 steps

1.1: toluene-4-sulfonic acid / ethanol / 1.5 h / Reflux

2.1: trichlorophosphate / 1,2-dichloro-benzene / 1.5 h / 20 °C

2.2: 4 h / 105 °C

2.3: 20 °C

3.1: 3 h / 115 °C / Inert atmosphere

3.2: 1 h / 20 °C / Molecular sieve; Inert atmosphere

4.1: sodium carbonate; p-toluenesulfonyl chloride / tetrahydrofuran; water / 2 h / 20 °C

4.2: 12 h

4.3: 0 °C / pH 10

5.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C

5.2: 0 - 20 °C

With sodium hydride; sodium carbonate; toluene-4-sulfonic acid; p-toluenesulfonyl chloride; trichlorophosphate; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide; 1,2-dichloro-benzene; 2.1: Vilsmeier-Haack reaction / 2.2: Vilsmeier-Haack reaction;

DOI:10.1016/j.bmc.2011.07.020

upstream raw materials:

9-methoxyellipticine

water

methyl iodide

5-methoxylindole

Downstream raw materials:

6-methyl-9-hydroxyellipticine