Quinoline, 2-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-

Base Information

• Chemical Name: Quinoline, 2-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-
• CAS No.: 57961-94-1
• Molecular Formula: C₂₂H₂₅N₃O
• Molecular Weight: 347.46
• DSSTox Substance ID: DTXSID00206681
• Wikidata: Q83080536
• Mol file: 57961-94-1.mol

Synonyms:57961-94-1;BRN 0898633;Quinoline, 2-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-;2-(2-(4-(2-Methoxyphenyl)-1-piperazinyl)ethyl)quinoline;2-(2-(4-(2-METHOXYPHENYL)-(PIPERAZIN-1-YL))ETHYL)QUINOLINE;SCHEMBL6192921;DTXSID00206681;LS-142030

Chemical Property of Quinoline, 2-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-

Chemical Property:

• Vapor Pressure: 2.25E-10mmHg at 25°C
• Boiling Point: 506.3°C at 760 mmHg
• Flash Point: 260°C
• Density: 1.149g/cm³
• XLogP3: 4.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 5
• Exact Mass: 347.199762429
• Heavy Atom Count: 26
• Complexity: 424

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=CC=C1N2CCN(CC2)CCC3=NC4=CC=CC=C4C=C3

Technology Process of Quinoline, 2-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-

There total 4 articles about Quinoline, 2-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-methylquinoline (91-63-4) → 2-{2-[4-(2-methoxy-phenyl)-piperazin-1-yl]-ethyl}-quinoline (57961-94-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 40 percent

2: (CH₃)2SO₄, Et₃N

3: acetic acid / ethanol / 24 h

With acetic acid; triethylamine; dimethyl sulfate; In ethanol;

Reference yield:

β-N,N-dimethylaminoethylquinaldine (63487-23-0) → 2-{2-[4-(2-methoxy-phenyl)-piperazin-1-yl]-ethyl}-quinoline (57961-94-1)

Guidance literature:

Multi-step reaction with 2 steps

1: (CH₃)2SO₄, Et₃N

2: acetic acid / ethanol / 24 h

With acetic acid; triethylamine; dimethyl sulfate; In ethanol;

Reference yield:

2-vinylquinoline (772-03-2) + 1-(2-Methoxyphenyl)piperazine (35386-24-4) → 2-{2-[4-(2-methoxy-phenyl)-piperazin-1-yl]-ethyl}-quinoline (57961-94-1)

Guidance literature:

With acetic acid; In ethanol; for 24h;

upstream raw materials:

2-vinylquinoline

1-(2-Methoxyphenyl)piperazine

2-methylquinoline

β-N,N-dimethylaminoethylquinaldine

Downstream raw materials:

1-[2-(1,2,3,4-Tetrahydroquinoline-2-yl)ethyl]-4-(2-methoxyphenyl)piperazine