Carbamic acid, (2-hydroxy-2-phenylethyl)-, ethyl ester

Base Information

• Chemical Name: Carbamic acid, (2-hydroxy-2-phenylethyl)-, ethyl ester
• CAS No.: 109355-73-9
• Molecular Formula: C11H15NO3
• Molecular Weight: 209.245
• DSSTox Substance ID: DTXSID30436656
• Nikkaji Number: J498.653I
• Mol file: 109355-73-9.mol

Synonyms:109355-73-9;Carbamic acid, (2-hydroxy-2-phenylethyl)-, ethyl ester;SCHEMBL10441979;DTXSID30436656;(beta-Hydroxyphenethyl)carbamic acid ethyl ester

Chemical Property of Carbamic acid, (2-hydroxy-2-phenylethyl)-, ethyl ester

Chemical Property:

• XLogP3: 1.2
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 5
• Exact Mass: 209.10519334
• Heavy Atom Count: 15
• Complexity: 190

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC(=O)NCC(C1=CC=CC=C1)O

Technology Process of Carbamic acid, (2-hydroxy-2-phenylethyl)-, ethyl ester

There total 15 articles about Carbamic acid, (2-hydroxy-2-phenylethyl)-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

α-(ethoxycarbonylamino)acetophenone (59840-70-9) → ethyl 2-hydroxy-2-phenylethylcarbamate (109355-73-9)

Guidance literature:

With sodium tetrahydroborate; In ethanol; at 0 ℃; for 6h;

DOI:10.1246/bcsj.66.1216

Reference yield: 73.0%

styrene (100-42-5,25038-60-2,25247-68-1,28213-80-1,28325-75-9,79637-11-9,9003-53-6) + ethyl N-<<(4-methylphenyl)sulphonyl>oxy>carbamate (54145-10-7) → ethyl 2-hydroxy-2-phenylethylcarbamate (109355-73-9) + ethyl 2-hydroxy-1-phenylethylcarbamate

Guidance literature:

With potassium osmate(VI) dihydrate; water; In acetonitrile; at 0 - 20 ℃; regioselective reaction;

DOI:10.1021/jo301372y

Reference yield: 42.0%

chloroformic acid ethyl ester (541-41-3) + 2-Amino-1-phenylethanol (7568-93-6,1936-63-6) → ethyl 2-hydroxy-2-phenylethylcarbamate (109355-73-9)

Guidance literature:

With pyridine; In dichloromethane;

upstream raw materials:

α-(ethoxycarbonylamino)acetophenone

ethyl (2-chloro-2-phenylethyl)carbamate

chloroformic acid ethyl ester

2-Amino-1-phenylethanol

Downstream raw materials:

ethyl-N-(2-phenethyl)carbamate

Butyric acid (R)-2-ethoxycarbonylamino-1-phenyl-ethyl ester

Butyric acid (S)-2-ethoxycarbonylamino-1-phenyl-ethyl ester

Acetic acid (S)-2-ethoxycarbonylamino-1-phenyl-ethyl ester