Technology Process of Phosphonic acid, (5-phenyl-2,4-pentadienyl)-, diethyl ester, (Z,E)-
There total 6 articles about Phosphonic acid, (5-phenyl-2,4-pentadienyl)-, diethyl ester, (Z,E)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
diethyl {2-[(1-phenyl-1H-tetrazol-5-yl)sulfonyl]ethyl}phosphonate;
With
potassium hexamethylsilazane;
In
tetrahydrofuran;
at -78 ℃;
for 0.0833333h;
Inert atmosphere;
(E)-3-phenylpropenal;
In
tetrahydrofuran;
at -78 - 0 ℃;
for 1.33333h;
optical yield given as %de;
chemoselective reaction;
Inert atmosphere;
DOI:10.1021/ol203431e
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: tetra-(n-butyl)ammonium iodide; potassium carbonate / N,N-dimethyl-formamide / 12 h / Inert atmosphere
1.2: 12 h / Inert atmosphere
2.1: potassium hexamethylsilazane / tetrahydrofuran / 0.08 h / -78 °C / Inert atmosphere
2.2: 1.33 h / -78 - 0 °C / Inert atmosphere
With
tetra-(n-butyl)ammonium iodide; potassium hexamethylsilazane; potassium carbonate;
In
tetrahydrofuran; N,N-dimethyl-formamide;
2.1: Julia-Kocienski olefination reaction / 2.2: Julia-Kocienski olefination reaction;
DOI:10.1021/ol203431e
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 96 percent / dry HCl / methanol / 20 h / Ambient temperature
2: 1.) diisobutylaluminum hydride, 2.) MeOH / 1.) benzene, toluene, 45 deg C, 3 h, 2.) benzene, toluene
3: 80 percent / phosphorus tribromide / diethyl ether / 1.5 h / 0 °C
4: 20 h / 160 °C
With
hydrogenchloride; methanol; phosphorus tribromide; diisobutylaluminium hydride;
In
methanol; diethyl ether;
DOI:10.1021/jo00227a020
