Guanosine, 2'-deoxy-N-(2-methyl-1-oxopropyl)-, 3'-benzoate 5'-[2-chlorophenyl [2-(triphenylmethoxy)ethyl]phosphoramidate]

Base Information

Chemical Name:Guanosine, 2'-deoxy-N-(2-methyl-1-oxopropyl)-, 3'-benzoate 5'-[2-chlorophenyl [2-(triphenylmethoxy)ethyl]phosphoramidate]
CAS No.:109875-63-0
Molecular Formula:C₄₈H₄₆ClN₆O₉P
Molecular Weight:917.355
Hs Code.:
Mol file:109875-63-0.mol

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Guanosine, 2'-deoxy-N-(2-methyl-1-oxopropyl)-, 3'-benzoate 5'-[2-chlorophenyl [2-(triphenylmethoxy)ethyl]phosphoramidate]

Chemical Property:

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Technology Process of Guanosine, 2'-deoxy-N-(2-methyl-1-oxopropyl)-, 3'-benzoate 5'-[2-chlorophenyl [2-(triphenylmethoxy)ethyl]phosphoramidate]

There total 4 articles about Guanosine, 2'-deoxy-N-(2-methyl-1-oxopropyl)-, 3'-benzoate 5'-[2-chlorophenyl [2-(triphenylmethoxy)ethyl]phosphoramidate] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 76-83-5
trityl chloride

: 109875-63-0
Benzoic acid (2R,3S,5R)-2-[(2-chloro-phenoxy)-(2-trityloxy-ethylamino)-phosphoryloxymethyl]-5-(2-isobutyrylamino-6-oxo-1,6-dihydro-purin-9-yl)-tetrahydro-furan-3-yl ester

Guidance literature:: Multi-step reaction with 3 steps

1: diisopropylethylamine / CH₂Cl₂ / 2 h

2: 82 percent / hydrazine hydrate (NH₂NH₂*H₂O) / methanol / 1 h

With hydrazine hydrate; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane;
DOI:10.1248/cpb.35.2726

Reference yield:

: 2-(2-Trityloxy-ethylamino)-indan-1,3-dione

: 109875-63-0
Benzoic acid (2R,3S,5R)-2-[(2-chloro-phenoxy)-(2-trityloxy-ethylamino)-phosphoryloxymethyl]-5-(2-isobutyrylamino-6-oxo-1,6-dihydro-purin-9-yl)-tetrahydro-furan-3-yl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 82 percent / hydrazine hydrate (NH₂NH₂*H₂O) / methanol / 1 h

With hydrazine hydrate; In methanol;
DOI:10.1248/cpb.35.2726

Reference yield:

: 15074-54-1
2-chlorophenyl dichlorophosphate

: 109875-63-0
Benzoic acid (2R,3S,5R)-2-[(2-chloro-phenoxy)-(2-trityloxy-ethylamino)-phosphoryloxymethyl]-5-(2-isobutyrylamino-6-oxo-1,6-dihydro-purin-9-yl)-tetrahydro-furan-3-yl ester

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine / CH₂Cl₂ / 0.25 h / 0 °C

With pyridine; In dichloromethane;
DOI:10.1248/cpb.35.2726