(2-bromoethyl)(diphenyl)phosphane oxide

Base Information

• Chemical Name: (2-bromoethyl)(diphenyl)phosphane oxide
• CAS No.: 5055-14-1
• Molecular Formula: C14H14BrOP
• Molecular Weight: 309.142
• Mol file: 5055-14-1.mol

Synonyms:

Chemical Property of (2-bromoethyl)(diphenyl)phosphane oxide

Chemical Property:

• Vapor Pressure: 1.82E-05mmHg at 25°C
• Boiling Point: 374.3°C at 760 mmHg
• Flash Point: 180.2°C
• Density: 1.38g/cm³

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (2-bromoethyl)(diphenyl)phosphane oxide

There total 4 articles about (2-bromoethyl)(diphenyl)phosphane oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.7%

Diphenylphosphonigsaeure-trimethylsilylester (13683-01-7) + ethylene dibromide (106-93-4) → diphenyl(β-bromoethyl)phosphine oxide (5055-14-1)

Guidance literature:

In neat (no solvent); for 0.5h; Inert atmosphere; Reflux;

DOI:10.1134/S1070363212120055

Reference yield:

chloro-diphenylphosphine (1079-66-9,74391-44-9) + ethylene dibromide (106-93-4) → diphenyl(β-bromoethyl)phosphine oxide (5055-14-1)

Guidance literature:

Multistep reaction; (i) EtOH, Py, Et₂O, (ii) /BRN= 605266/;

DOI:10.1021/jm00321a037

Reference yield:

diphenyl-phosphinic acid (1707-03-5) → diphenyl(β-bromoethyl)phosphine oxide (5055-14-1)

Guidance literature:

Multi-step reaction with 2 steps

1: neat (no solvent) / Reflux

2: neat (no solvent) / 0.5 h / Inert atmosphere; Reflux

In neat (no solvent);

DOI:10.1134/S1070363212120055

upstream raw materials:

chloro-diphenylphosphine

ethylene dibromide

Diphenylphosphonigsaeure-trimethylsilylester

diphenyl-phosphinic acid

Downstream raw materials:

ethyl 2-amino-2-methyl-4-(diphenylphosphinoyl)butyrate

vinyldiphenylphosphine oxide

Refernces

• 1、 Struck,Shealy. "Tertiary phosphines and phosphine oxides containing a 2-haloethyl group.". . p. 414 - 416. Retrieved 2007/10/05.