Phosphonous dichloride, (chloromethyl)-

Base Information

• Chemical Name: Phosphonous dichloride, (chloromethyl)-
• CAS No.: 2155-78-4
• Molecular Formula: CH2Cl3P
• Molecular Weight: 151.36
• DSSTox Substance ID: DTXSID20175885
• Nikkaji Number: J1.455.077A
• Wikidata: Q83046219
• Mol file: 2155-78-4.mol

Synonyms:Phosphonous dichloride, (chloromethyl)-;2155-78-4;Chloromethyldichlorophosphine;Dichloro(chloromethyl)phosphine;SCHEMBL2134002;DTXSID20175885

Chemical Property of Phosphonous dichloride, (chloromethyl)-

Chemical Property:

• Vapor Pressure: 3.44mmHg at 25°C
• Boiling Point: 158.2°C at 760 mmHg
• Flash Point: 49.5°C
• PSA: 13.59000
• LogP: 2.97220
• XLogP3: 2.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 0
• Rotatable Bond Count: 0
• Exact Mass: 149.895970
• Heavy Atom Count: 5
• Complexity: 20.9

Purity/Quality:

99% ^*data from raw suppliers

DICHLORO(CHLOROMETHYL)PHOSPHANE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C(P(Cl)Cl)Cl

Technology Process of Phosphonous dichloride, (chloromethyl)-

There total 8 articles about Phosphonous dichloride, (chloromethyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

P-(chloromethyl)-N,N,N',N'-tetraisopropylphosphonous diamide (124862-12-0) → dichloro(chloromethyl)phosphine (2155-78-4) + diisopropylamine hydrochloride (819-79-4)

Guidance literature:

With hydrogenchloride; In diethyl ether; -70 deg C --> room temperature;

Reference yield: 78.0%

(chloromethyl)phosphonothioic acid dichloride (1983-27-3) → dichloro(chloromethyl)phosphine (2155-78-4)

Guidance literature:

With tributylphosphine; at 0 - 5 ℃; for 1.5h;

Reference yield: 50.0%

P-(chloromethyl)-N,N,N',N'-tetraisopropylphosphonous diamide (124862-12-0) → dichloro(chloromethyl)phosphine (2155-78-4)

Guidance literature:

With hydrogenchloride; In diethyl ether; at -70 ℃;

DOI:10.1016/S0040-4039(01)80423-8

upstream raw materials:

diazomethane

dichloromethane

(chloromethyl)phosphonothioic acid dichloride

methyl dichlorophosphite

Downstream raw materials:

tetrachloro(trichloromethyl)phosphorane

chloromethylphosphonic dichloride

{((CH₃)2CH)2C₆H₃}OPClCH₂Cl

2-phenyl-3H-1,3,4-diazaphosphole

Refernces

• 1、 Antczak, Monika I.,Montchamp, Jean-Luc. "Mild synthesis of organophosphorus compounds: Reaction of phosphorus-containing carbenoids with organoboranes". supporting information; experimental part. p. 977 - 980. Retrieved 2009/04/10.
• 2、 Veken, B. J. van der,Sanders, R. S.,Harlan, R. J.,Durig, J. R.. "Spectra and structure of phosphorus-boron compounds - XXVII. Low-resolution microwave, IR and Raman spectra, conformational stability, ab initio calculations, vibrational assignment and normal coordinate calculations for (chloromethyl)difluorophosphine borane.". . p. 1833 - 1872. Retrieved 2007/10/02.