(3-Bromo-4-hydroxybenzylidene)malonic acid

Base Information

• Chemical Name: (3-Bromo-4-hydroxybenzylidene)malonic acid
• CAS No.: 73747-61-2
• Molecular Formula: C₁₀H₇BrO₅
• Molecular Weight: 287.067
• Mol file: 73747-61-2.mol

Synonyms:MALONIC ACID,(3-BROMO-4-HYDROXYBENZYLIDENE);(3-Bromo-4-hydroxybenzylidene)malonic acid;

Chemical Property of (3-Bromo-4-hydroxybenzylidene)malonic acid

Chemical Property:

• Vapor Pressure: 4.74E-09mmHg at 25°C
• Boiling Point: 454.5°C at 760 mmHg
• Flash Point: 228.7°C
• PSA: 94.83000
• Density: 1.906g/cm³
• LogP: 1.70730

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (3-Bromo-4-hydroxybenzylidene)malonic acid

There total 3 articles about (3-Bromo-4-hydroxybenzylidene)malonic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-hydroxy-benzaldehyde (123-08-0,65581-83-1) → (3-bromo-4-hydroxy-benzylidene)-malonic acid (73747-61-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 94 percent / Br₂

2: Knoevenagel condensation

With bromine;

DOI:10.1016/S0040-4039(00)71158-0

Reference yield:

malonic acid (141-82-2) + 3-bromo-4-hydroxybenzylaldehyde (2973-78-6) → (3-bromo-4-hydroxy-benzylidene)-malonic acid (73747-61-2)

Guidance literature:

Yield given; Knoevenagel condensation;

DOI:10.1016/S0040-4039(00)71158-0

Reference yield:

→ (3-bromo-4-hydroxy-benzylidene)-malonic acid (73747-61-2)

Guidance literature:

/BRN= 3340898/;

upstream raw materials:

malonic acid

3-bromo-4-hydroxybenzylaldehyde

4-hydroxy-benzaldehyde

Downstream raw materials:

3-bromo-4-hydroxy cinnamic acid

methyl 3-bromo-4-hydroxycinnamate

(E)-3-(3-Bromo-4-methoxymethoxy-phenyl)-acrylic acid methyl ester