3-BROMO-4-HYDROXYCINNAMIC ACID

Base Information

• Chemical Name: 3-BROMO-4-HYDROXYCINNAMIC ACID
• CAS No.: 119405-32-2
• Molecular Formula: C9H7 Br O3
• Molecular Weight: 243.057
• Mol file: 119405-32-2.mol

Synonyms:3-BROMO-4-HYDROXYCINNAMIC ACID;

Chemical Property of 3-BROMO-4-HYDROXYCINNAMIC ACID

Chemical Property:

• PSA: 57.53000
• LogP: 2.25250

Purity/Quality:

99%min ^*data from raw suppliers

3-bromo-4-hydroxycinnamicacid 95 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-BROMO-4-HYDROXYCINNAMIC ACID

There total 5 articles about 3-BROMO-4-HYDROXYCINNAMIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

malonic acid (141-82-2) + 3-bromo-4-hydroxybenzylaldehyde (2973-78-6) → 3-bromo-4-hydroxy cinnamic acid (119405-32-2)

Guidance literature:

With piperidine; pyridine; at 80 ℃; for 5h;

DOI:10.1016/j.jphotochem.2020.112738

Reference yield:

(3-bromo-4-hydroxy-benzylidene)-malonic acid (73747-61-2) → 3-bromo-4-hydroxy cinnamic acid (119405-32-2)

Guidance literature:

With piperidine; In pyridine; Yield given; Heating;

DOI:10.1016/S0040-4039(00)71158-0

Reference yield:

3-bromo-4-hydroxybenzylaldehyde (2973-78-6) → 3-bromo-4-hydroxy cinnamic acid (119405-32-2)

Guidance literature:

Multi-step reaction with 2 steps

1: Knoevenagel condensation

2: piperidine / pyridine / Heating

With piperidine; In pyridine;

DOI:10.1016/S0040-4039(00)71158-0

upstream raw materials:

malonic acid

3-bromo-4-hydroxybenzylaldehyde

(3-bromo-4-hydroxy-benzylidene)-malonic acid

4-hydroxy-benzaldehyde

Downstream raw materials:

(E)-3-(3-Bromo-4-methoxymethoxy-phenyl)-acrylic acid methyl ester

methyl 3-bromo-4-hydroxycinnamate

Refernces

• 1、 Gupta,Ray,Banerjee,Ghosh,Roy,Fouzdar Gupta. "A quantitative structure-activity relationship study of the antifungal properties of some cinnamic acid derivatives using lipophilicity (log P), second order molecular connectivity (2χ(v)) and information content (1IC)". . p. 187 - 191. Retrieved 2007/10/02.