6-BROMO-3-PHENYL-2-QUINOLINOL

Base Information

• Chemical Name: 6-BROMO-3-PHENYL-2-QUINOLINOL
• CAS No.: 110486-57-2
• Molecular Formula: C15H10BrNO
• Molecular Weight: 300.15000
• Hs Code.: 2933499090
• Mol file: 110486-57-2.mol

Synonyms:6-Bromo-3-phenyl-2-quinolinol;6-Bromo-2-hydroxy-3-phenylquinoline;2(1H)-Quinolinone,6-bromo-3-phenyl;

Chemical Property of 6-BROMO-3-PHENYL-2-QUINOLINOL

Chemical Property:

• Vapor Pressure: 2.7E-09mmHg at 25°C
• Melting Point: 256-259 °C(Solv: ligroine (8032-32-4); acetone (67-64-1))
• Boiling Point: 465.7oC at 760 mmHg
• PKA: 10.32±0.70(Predicted)
• Flash Point: 235.5oC
• PSA: 33.12000
• Density: 1.526g/cm3
• LogP: 4.36990

Purity/Quality:

97% ^*data from raw suppliers

6-BROMO-2-HYDROXY-3-PHENYLQUINOLINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-BROMO-3-PHENYL-2-QUINOLINOL

There total 10 articles about 6-BROMO-3-PHENYL-2-QUINOLINOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

→ 6-bromo-3,4-dihydro-3-phenylcarbostyril (113092-91-4) + 6-bromo-3-phenylquinolin-2(1H)-one (110486-57-2)

Guidance literature:

With bromine; In chloroform; for 6h; Heating;

DOI:10.1248/cpb.35.2819

Reference yield: 75.0%

4-bromo-2-iodoaniline (66416-72-6) + oxalic acid (144-62-7,97993-78-7) + phenylacetylene (536-74-3) → 6-bromo-3-phenylquinolin-2(1H)-one (110486-57-2)

Guidance literature:

With tetra-(n-butyl)ammonium iodide; In N,N-dimethyl-formamide; at 135 ℃; for 1h; regioselective reaction; Microwave irradiation;

DOI:10.1002/adsc.201801127

Reference yield: 72.0%

C15H8BrN → 6-bromo-3-phenylquinolin-2(1H)-one (110486-57-2)

Guidance literature:

With water; silver nitrate; In N,N-dimethyl-formamide; at 80 ℃; for 2h;

DOI:10.1039/c8ob01882k

upstream raw materials:

3-phenyl-1,2,3,4-tetrahydro-2-quinolone

6-bromo-3,4-dihydro-3-phenylcarbostyril

(E)-2-phenyl-3-(2-nitrophenyl)propenoic acid

4-bromo-2-iodoaniline

Downstream raw materials:

6-bromo-2-chloro-3-phenylquinoline

2-[4-(6-Bromo-3-phenyl-quinolin-2-yl)-piperazin-1-yl]-ethanol

6-Bromo-2-(4-methyl-piperazin-1-yl)-3-phenyl-quinoline

[2-(6-Bromo-3-phenyl-quinolin-2-ylsulfanyl)-ethyl]-dimethyl-amine

Refernces

• 1、 Charoenpol, Ailada,Meesin, Jatuporn,Khaikate, Onnicha,Reutrakul, Vichai,Pohmakotr, Manat,Leowanawat, Pawaret,Soorukram, Darunee,Kuhakarn, Chutima. "Synthesis of 3-substituted quinolin-2(1H)-ones via the cyclization of o-alkynylisocyanobenzenes". supporting information. p. 7050 - 7054. Retrieved 2018/10/17.
• 2、 Hino,Nagai,Uno. "Synthesis and pharmacological activities of 3-phenyl-2-(1-piperazinyl)quinolines and related compounds". . p. 2819 - 2824. Retrieved 2007/10/02.