1-(Phenylsulfonyl)-1H-indole-3-acrylic acid ethyl ester

Base Information

Chemical Name:1-(Phenylsulfonyl)-1H-indole-3-acrylic acid ethyl ester
CAS No.:110604-89-2
Molecular Formula:C₁₉H₁₇NO₄S
Molecular Weight:355.414
Hs Code.:
Nikkaji Number:J3.062.369J,J505.675F
Mol file:110604-89-2.mol

Synonyms:1-(Phenylsulfonyl)-1H-indole-3-acrylic acid ethyl ester;(E)-3-[1-(Phenylsulfonyl)-1H-indol-3-yl]acrylic acid ethyl ester

Suppliers and Price of 1-(Phenylsulfonyl)-1H-indole-3-acrylic acid ethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-(Phenylsulfonyl)-1H-indole-3-acrylic acid ethyl ester

Chemical Property:

XLogP3:3.9
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:6
Exact Mass:355.08782920
Heavy Atom Count:25
Complexity:589

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC(=O)C=CC1=CN(C2=CC=CC=C21)S(=O)(=O)C3=CC=CC=C3
Isomeric SMILES:CCOC(=O)/C=C/C1=CN(C2=CC=CC=C21)S(=O)(=O)C3=CC=CC=C3

Technology Process of 1-(Phenylsulfonyl)-1H-indole-3-acrylic acid ethyl ester

There total 5 articles about 1-(Phenylsulfonyl)-1H-indole-3-acrylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 129271-97-2
1-(phenylsulfonyl)indol-3-yl trifluoromethanesulfonate

: 140-88-5,9003-32-1
ethyl acrylate

: 90734-67-1,110604-89-2
1-(Phenylsulfonyl)-3-<(β-ethoxycarbonyl)vinyl>indole

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 70 - 80 ℃;
DOI:10.1080/00397919208019065

Reference yield: 49.0%

: 867-13-0
diethoxyphosphoryl-acetic acid ethyl ester

: 80360-20-9
1-(phenylsulfonyl)indole-3-carbaldehyde

: 90734-67-1,110604-89-2
ethyl 3-(N-benzenesulfonyl-3-indolyl)acrylate

Guidance literature:: With n-butyllithium; In tetrahydrofuran; hexane; for 10h; Ambient temperature;
DOI:10.1248/cpb.35.2261

Reference yield:

: 487-89-8,1228547-52-1
Indole-3-carboxaldehyde

: 90734-67-1,110604-89-2
ethyl 3-(N-benzenesulfonyl-3-indolyl)acrylate

Guidance literature:: Multi-step reaction with 2 steps

1: 87 percent / NaH / dimethylsulfoxide / 1 h / 60 °C

2: 49 percent / n-BuLi / tetrahydrofuran; hexane / 10 h / Ambient temperature

With n-butyllithium; sodium hydride; In tetrahydrofuran; hexane; dimethyl sulfoxide;
DOI:10.1248/cpb.35.2261