Methanimidic acid, N-[4-cyano-1-(phenylmethyl)-1H-imidazol-5-yl]-, methyl ester

Base Information

• Chemical Name: Methanimidic acid, N-[4-cyano-1-(phenylmethyl)-1H-imidazol-5-yl]-, methyl ester
• CAS No.: 111267-84-6
• Molecular Formula: C13H12N4O
• Molecular Weight: 240.264
• Mol file: 111267-84-6.mol

Synonyms:

Chemical Property of Methanimidic acid, N-[4-cyano-1-(phenylmethyl)-1H-imidazol-5-yl]-, methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methanimidic acid, N-[4-cyano-1-(phenylmethyl)-1H-imidazol-5-yl]-, methyl ester

There total 4 articles about Methanimidic acid, N-[4-cyano-1-(phenylmethyl)-1H-imidazol-5-yl]-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

5-amino-1-benzyl-1H-imidazole-4-carbonitrile (60598-48-3) + trimethyl orthoformate (149-73-5) → 1-benzyl-4-cyano-5-<(methoxymethylene)amino>imidazole (111267-84-6)

Guidance literature:

With trifluoroacetic acid; for 5h; Heating;

DOI:10.1081/SCC-100000581

Reference yield: 74.0%

5-amino-1-benzyl-1H-imidazole-4-carbonitrile (60598-48-3) + trimethyl orthoformate (149-73-5) → 1-benzyl-4-cyano-5[(methoxymethylene)amino]imidazole (111267-84-6)

Guidance literature:

With trifluoroacetic acid; In acetonitrile; at 105 ℃; for 1h;

DOI:10.1021/ja010756d

Reference yield:

N-amino-N-methyl-N'-(1-benzyl-4-cyanoimidazol-5-yl)-formamidine (111267-86-8) → 1-benzyl-4-cyano-5-<(methoxymethylene)amino>imidazole (111267-84-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 47 percent / trifluoroacetic acid / toluene; methanol / 72 h / Heating

2: 84 percent / trifluoroacetic acid / 4 h / Heating

With trifluoroacetic acid; In methanol; toluene;

DOI:10.1021/jo00237a028

upstream raw materials:

5-amino-1-benzyl-1H-imidazole-4-carbonitrile

trimethyl orthoformate

N-amino-N-methyl-N'-(1-benzyl-4-cyanoimidazol-5-yl)-formamidine

benzylamine

Downstream raw materials:

1-amino-9-benzyl-6-iminopurine

9-benzyl-6-hydrazino-9H-purine

N-amino-N-methyl-N'-(1-benzyl-4-cyanoimidazol-5-yl)-formamidine

9-benzyl-6-(β-methylhydrazino)purine