60598-48-3

Basic information

• Product Name: 5-amino-1-benzyl-1H-imidazole-4-carbonitrile
• Synonyms: 5-Amino-1-benzyl-1H-imidazole-4-carbonitrile
• CAS NO: 60598-48-3
• Molecular Formula: C₁₁H₁₀N₄
• Molecular Weight: 198.2239
• Mol File: 60598-48-3.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 469.1°C at 760 mmHg
• Flash Point: 237.5°C
• Density: 1.22g/cm³
• Vapor Pressure: 5.67E-09mmHg at 25°C
• Refractive Index: 1.649
• CAS DataBase Reference: 5-amino-1-benzyl-1H-imidazole-4-carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 5-amino-1-benzyl-1H-imidazole-4-carbonitrile(60598-48-3)
• EPA Substance Registry System: 5-amino-1-benzyl-1H-imidazole-4-carbonitrile(60598-48-3)

Safety Data

• Hazardous Substances Data: 60598-48-3(Hazardous Substances Data)

Upstream product

• 100-46-9 benzylamine 
• 358657-89-3 Ethyl (Z)-N-(2-amino-1,2-dicyanovinyl)formimidate 
• 3815-69-8 5-amino-1-(phenylmethyl)-1H-imidazole-4-carboxamide 
• 133123-63-4 N-(2-amino-1,2-dicyano-vinyl)-formimydic acid ethyl ester 
• 111267-84-6 1-benzyl-4-cyano-5-<(methoxymethylene)amino>imidazole 
• 111267-83-5 N-(dicyanomethyl)methanimidate 
• 111267-86-8 N-amino-N-methyl-N'-(1-benzyl-4-cyanoimidazol-5-yl)-formamidine 
• 100-39-0 benzyl bromide 
• 5098-11-3 5-amino-1H-imidazole-4-carbonitrile 

Downstream Products

• 565473-06-5 5-amino-1-benzyl-2-bromo-1H-imidazole-4-carbonitrile 
• 821004-32-4 3-acetamido-6-benzylimidazo[4,5-c]pyrazole 
• 821004-25-5 5-amino-1-benzyl-2-chloroimidazole-4-carboxamidoxime 
• 624737-77-5 9-benzyl-8-chloro-2-hydroxyadenine 
• 226907-93-3 6-Amino-9-benzyl-2-butylaminopurine 
• 111267-85-7 1-amino-9-benzyl-6-iminopurine 
• 111267-87-9 3-(5-amino-1-benzylimidazol-4-yl)-1-methyl-1,2,4-triazole 
• 116544-96-8 9-benzyl-6-(β-methylhydrazino)purine 
• 6268-73-1 9-benzyl-6-hydrazino-9H-purine 
• 64995-70-6 4-(benzylamino)-1-methylimidazole-5-carbonitrile 
• 1354640-95-1 5-amino-1-benzyl-4-cyano-3-methylimidazol-3-ium iodide 
• 914110-68-2 9-benzyl-8-bromo-2-(trichloromethyl)-9H-purin-6-amine 
• 914110-70-6 methyl 6-amino-9-benzyl-8-oxo-8,9-dihydro-7H-purine-2-carboxylate 
• 914110-60-4 methyl 6-amino-9-benzyl-8-methoxy-9H-purine-2-carboxylate 

Relevant articles and documents

PURINE DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS

The present invention relates to purine derivatives of formula (I), processes for their preparation, pharmaceutical compositions, and their use in treating viral infections.

2-AMIDO-6-AMINO-8-OXOPURINE DERIVATIVES AS TOLL-LIKE RECEPTOR MODULATORS FOR THE TREATMENT OF CANCER AND VIRAL INFECTIONS, SUCH AS HEPATITIS C

This invention relates to purine derivatives, to processes for their preparation, to compositions containing them and to their use. The present invention provides compounds of formula (I) wherein R1, R2, R3, R9, R9a and Y are defined in the description. More particularly, the present invention relates to the use of purine derivatives in the treatment of a variety of viral infections and immune or inflammatory disorders, including those in which the modulation, in particular agonism, of Toll-Like Receptors (TLRs) is implicated. Accordingly, the compounds of the invention are useful in the treatment of infectious disease such as Hepatitis (e.g. HCV, HBV), genetically related viral infections, inflammatory diseases such as asthma and arthritis, and cancer.

An improved synthesis of 9-benzyladenine: A model for adenosine and its analogues

An improved synthesis of 9-benzyladenine (I), a model for a variety of biologically and therapeutically significant adenine nucleosides, has been reported. The target compound was synthesized by condensation of 1-benzyl-4-cyano-5-methoxymethyleneiminoimidazole (14) with guanidine. Compound 14 was prepared from 5-amino-1-benzyl-4-cyanoimidazole (5), which in turn was prepared by reaction of benzylamine with ethyl (Z)-N-(2-amino-1,2-dicyanovinyl) formimidate (13). The latter was synthesized by reaction of diaminomaleonitrile (6) with triethyl orthoformate.