1,3-Benzodioxole-5-carboxylic acid, 7-[4-[2-[3-hydroxy-2-(phenylmethoxy)phenyl]ethyl]phenoxy]-2,2-dimethyl- , methyl ester

Base Information

Chemical Name:1,3-Benzodioxole-5-carboxylic acid, 7-[4-[2-[3-hydroxy-2-(phenylmethoxy)phenyl]ethyl]phenoxy]-2,2-dimethyl- , methyl ester
CAS No.:111436-66-9
Molecular Formula:C₃₂H₃₀O₇
Molecular Weight:526.586
Hs Code.:
Mol file:111436-66-9.mol

Synonyms:

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Chemical Property of 1,3-Benzodioxole-5-carboxylic acid, 7-[4-[2-[3-hydroxy-2-(phenylmethoxy)phenyl]ethyl]phenoxy]-2,2-dimethyl- , methyl ester

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Technology Process of 1,3-Benzodioxole-5-carboxylic acid, 7-[4-[2-[3-hydroxy-2-(phenylmethoxy)phenyl]ethyl]phenoxy]-2,2-dimethyl- , methyl ester

There total 7 articles about 1,3-Benzodioxole-5-carboxylic acid, 7-[4-[2-[3-hydroxy-2-(phenylmethoxy)phenyl]ethyl]phenoxy]-2,2-dimethyl- , methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.0%

: 100-39-0
benzyl bromide

: 96643-01-5
methyl 7-<4-<2-(2,3-dihydroxyphenyl)ethyl>phenoxy>-2,2-dimethyl-1,3-benzodioxole-5-carboxylate

: 96643-02-6
7-{4-[2-(3-Benzyloxy-2-hydroxy-phenyl)-ethyl]-phenoxy}-2,2-dimethyl-benzo[1,3]dioxole-5-carboxylic acid methyl ester

: 111436-66-9
7-{4-[2-(2-Benzyloxy-3-hydroxy-phenyl)-ethyl]-phenoxy}-2,2-dimethyl-benzo[1,3]dioxole-5-carboxylic acid methyl ester

Guidance literature:: With potassium carbonate; In acetone; Heating;
DOI:10.1021/jo00236a015

Reference yield:

: 81464-85-9
2,3-Bis(benzyloxy)benzyl bromide

: 111436-66-9
7-{4-[2-(2-Benzyloxy-3-hydroxy-phenyl)-ethyl]-phenoxy}-2,2-dimethyl-benzo[1,3]dioxole-5-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 74 percent / 3 h / 80 °C

2: 1.) potassium tert-butoxide / 1.) DMF, 0 deg C, 15 min, 2.) DMF, RT, 12 h

3: 96 percent / H₂ / 10percent Pd/C / methanol; ethyl acetate / 760 Torr / Ambient temperature

4: 20 percent / K₂CO₃ / acetone / Heating

With potassium tert-butylate; hydrogen; potassium carbonate; palladium on activated charcoal; In methanol; ethyl acetate; acetone;
DOI:10.1021/jo00236a015

Reference yield:

: 96642-97-6
methyl 7-hydroxy-2,2-dimethylbenzo[d][1,3]dioxole-5-carboxylate

: 111436-66-9
7-{4-[2-(2-Benzyloxy-3-hydroxy-phenyl)-ethyl]-phenoxy}-2,2-dimethyl-benzo[1,3]dioxole-5-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 68 percent / K₂CO₃, CuO, pyridine / 12 h / Heating

2: 1.) potassium tert-butoxide / 1.) DMF, 0 deg C, 15 min, 2.) DMF, RT, 12 h

3: 96 percent / H₂ / 10percent Pd/C / methanol; ethyl acetate / 760 Torr / Ambient temperature

4: 20 percent / K₂CO₃ / acetone / Heating

With pyridine; potassium tert-butylate; hydrogen; potassium carbonate; copper(II) oxide; palladium on activated charcoal; In methanol; ethyl acetate; acetone;
DOI:10.1021/jo00236a015