Imidazo(2,1-b)-1,3,4-thiadiazole, 5-bromo-6-phenyl-2-(3,4,5-trimethoxyphenyl)-

Base Information

Chemical Name:Imidazo(2,1-b)-1,3,4-thiadiazole, 5-bromo-6-phenyl-2-(3,4,5-trimethoxyphenyl)-
CAS No.:91918-75-1
Molecular Formula:C₁₉H₁₆BrN₃O₃S
Molecular Weight:446.324
Hs Code.:
DSSTox Substance ID:DTXSID00238780
Wikidata:Q83121095

Synonyms:5-Bromo-6-phenyl-2-(3,4,5-trimethoxyphenyl)imidazo(2,1-b)-1,3,4-thiadiazole;Imidazo(2,1-b)-1,3,4-thiadiazole, 5-bromo-6-phenyl-2-(3,4,5-trimethoxyphenyl)-;91918-75-1;DTXSID00238780;LS-80573

Suppliers and Price of Imidazo(2,1-b)-1,3,4-thiadiazole, 5-bromo-6-phenyl-2-(3,4,5-trimethoxyphenyl)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemical Property of Imidazo(2,1-b)-1,3,4-thiadiazole, 5-bromo-6-phenyl-2-(3,4,5-trimethoxyphenyl)-

Chemical Property:

PKA:-1.91±0.50(Predicted)
PSA：86.12000
Density:1.54g/cm³
LogP:4.91310
XLogP3:5.1
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:5
Exact Mass:445.00958
Heavy Atom Count:27
Complexity:485

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=CC(=CC(=C1OC)OC)C2=NN3C(=C(N=C3S2)C4=CC=CC=C4)Br

Technology Process of Imidazo(2,1-b)-1,3,4-thiadiazole, 5-bromo-6-phenyl-2-(3,4,5-trimethoxyphenyl)-

There total 3 articles about Imidazo(2,1-b)-1,3,4-thiadiazole, 5-bromo-6-phenyl-2-(3,4,5-trimethoxyphenyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 83805-45-2
2-(3,4,5-trimethoxyphenyl)-6-phenylimidazo<2,1-b>-1,3,4-thiadiazole

: 91918-75-1
5-Bromo-6-phenyl-2-(3,4,5-trimethoxy-phenyl)-imidazo[2,1-b][1,3,4]thiadiazole

Guidance literature:: With bromine; In acetic acid; for 0.5h; Ambient temperature;

Reference yield:

: 28004-59-3
2-(3,4,5-trimethoxyphenyl)-5-amino-1,3,4-thiadiazole

: 91918-75-1
5-Bromo-6-phenyl-2-(3,4,5-trimethoxy-phenyl)-imidazo[2,1-b][1,3,4]thiadiazole

Guidance literature:: Multi-step reaction with 2 steps

1: 65 percent / dimethylformamide; ethanol / 3 h / Heating

2: 60 percent / Br₂ / acetic acid / 0.5 h / Ambient temperature

With bromine; In ethanol; acetic acid; N,N-dimethyl-formamide;

Reference yield:

: 70-11-1
α-bromoacetophenone

: 91918-75-1
5-Bromo-6-phenyl-2-(3,4,5-trimethoxy-phenyl)-imidazo[2,1-b][1,3,4]thiadiazole

Guidance literature:: Multi-step reaction with 2 steps

1: 65 percent / dimethylformamide; ethanol / 3 h / Heating

2: 60 percent / Br₂ / acetic acid / 0.5 h / Ambient temperature

With bromine; In ethanol; acetic acid; N,N-dimethyl-formamide;