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6-phenyl-2-(3,4,5-trimethoxyphenyl)imidazo[2,1-b][1,3,4]thiadiazole is a complex organic compound characterized by its unique molecular structure. It features an imidazothiadiazole core, which is a heterocyclic ring system consisting of an imidazole (a five-membered ring with two nitrogen atoms) fused to a thiadiazole (a five-membered ring with one nitrogen and two sulfur atoms). The compound is further defined by a phenyl group attached at the 6-position and a 3,4,5-trimethoxyphenyl group at the 2-position. The trimethoxyphenyl group is notable for its three methoxy substituents, which are electron-donating groups that can influence the compound's reactivity and physical properties. This chemical is likely to be found in specialized applications due to its specific structure, potentially in areas such as pharmaceuticals, materials science, or as a chemical intermediate.

83805-45-2

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83805-45-2 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 83805-45-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,3,8,0 and 5 respectively; the second part has 2 digits, 4 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 83805-45:
(7*8)+(6*3)+(5*8)+(4*0)+(3*5)+(2*4)+(1*5)=142
142 % 10 = 2
So 83805-45-2 is a valid CAS Registry Number.
InChI:InChI=1/C19H17N3O3S/c1-23-15-9-13(10-16(24-2)17(15)25-3)18-21-22-11-14(20-19(22)26-18)12-7-5-4-6-8-12/h4-11H,1-3H3

83805-45-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name 6-phenyl-2-(3,4,5-trimethoxyphenyl)imidazo[2,1-b][1,3,4]thiadiazole

1.2 Other means of identification

Product number -
Other names HMS1664L19

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

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More Details:83805-45-2 SDS

83805-45-2Relevant academic research and scientific papers

Synthesis and biological evaluation of imidazo[2,1-b][1,3,4]thiadiazole- linked oxindoles as potent tubulin polymerization inhibitors

Kamal, Ahmed,Rao, M. P. Narasimha,Das, Pompi,Swapna,Polepalli, Sowjanya,Nimbarte, Vijaykumar D.,Mullagiri, Kishore,Kovvuri, Jeshma,Jain, Nishant

, p. 1463 - 1475 (2014/07/21)

A series of imidazo[2,1-b][1,3,4]thiadiazole-linked oxindoles composed of an A, B, C and D ring system were synthesized and investigated for anti-proliferative activity in various human cancer cell lines; test compounds were variously substituted at rings C and D. Among them, compounds 7 ((E)-5-fluoro-3-((6-p-tolyl-2-(3,4,5-trimethoxyphenyl)-imidazo[2,1-b][1,3,4] thiadiazol-5-yl)methylene)indolin-2-one), 11 ((E)-3-((6-p-tolyl-2-(3,4,5- trimethoxyphenyl)imidazo[2,1-b][1,3,4]thiadiazol-5-yl)methylene)indolin-2-one), and 15 ((E)-6-chloro-3-((6-phenyl-2-(3,4,5-trimethoxyphenyl)imidazo[2,1-b][1,3, 4]thiadiazol-5-yl)methylene)indolin-2-one) exhibited potent anti-proliferative activity. Treatment with these three compounds resulted in accumulation of cells in G2/M phase, inhibition of tubulin assembly, and increased cyclin-B1 protein levels. Compound 7 displayed potent cytotoxicity, with an IC50 range of 1.1-1.6 μM, and inhibited tubulin polymerization with an IC50 value (0.15 μM) lower than that of combretastatin A-4 (1.16 μM). Docking studies reveal that compounds 7 and 11 bind with αAsn101, βThr179, and βCys241 in the colchicine binding site of tubulin. Imidazzling microtubule blockers! A series of imidazo[2,1-b][1,3,4] thiadiazole-linked oxindole conjugates were synthesized and evaluated for anticancer potential. Conjugate 7 displayed promising cytotoxicity, arrested cells at the G2/M phase, and showed potent tubulin polymerization inhibition with an IC50 value of 0.15 μM.

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