6,7-Dimethoxy-1-phenyl-1,2,3,4-tetrahydroisoquinoline

Base Information

Chemical Name:6,7-Dimethoxy-1-phenyl-1,2,3,4-tetrahydroisoquinoline
CAS No.:4118-36-9
Molecular Formula:C17H19 N O2
Molecular Weight:269.343
Hs Code.:2933499090
European Community (EC) Number:834-857-4
DSSTox Substance ID:DTXSID60961486
Nikkaji Number:J480.446E
ChEMBL ID:CHEMBL258275
Mol file:4118-36-9.mol

Synonyms:1-phenyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline;1-phenyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride;1-phenyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride, (+-)-isomer;6,7-dimethoxy-4-phenyl-1,2,3,4-tetrahydroisoquinoline;S-23

Suppliers and Price of 6,7-Dimethoxy-1-phenyl-1,2,3,4-tetrahydroisoquinoline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 13 raw suppliers

Chemical Property of 6,7-Dimethoxy-1-phenyl-1,2,3,4-tetrahydroisoquinoline

Chemical Property:

Vapor Pressure:1.23E-06mmHg at 25°C
Melting Point:127-128ºC
Boiling Point:400.9°Cat760mmHg
PKA:8.26±0.40(Predicted)
Flash Point:167.1°C
PSA：30.49000
Density:1.101g/cm³
LogP:3.26770
XLogP3:3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:269.141578849
Heavy Atom Count:20
Complexity:303

Purity/Quality:: 99%, ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=C(C=C2C(NCCC2=C1)C3=CC=CC=C3)OC

Technology Process of 6,7-Dimethoxy-1-phenyl-1,2,3,4-tetrahydroisoquinoline

There total 29 articles about 6,7-Dimethoxy-1-phenyl-1,2,3,4-tetrahydroisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: C₁₇H₁₇NO₂*H⁽¹⁺⁾

: 4118-36-9
6,7-dimethoxy-1-phenyl-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: With [Cp*Ir-(4,4’-dimethoxyl-2,2’-bipyridine)(OH₂)][SO₄]; 1-Benzyl-1,4-dihydronicotinamide; In aq. phosphate buffer; at 20 ℃; for 24h; pH=7;
DOI:10.1002/cctc.201601307

Reference yield: 98.0%

: 100-52-7
benzaldehyde

: 120-20-7
2-(3,4-dimethoxyphenyl)-ethylamine

: 4118-36-9
6,7-dimethoxy-1-phenyl-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: benzaldehyde; 2-(3,4-dimethoxyphenyl)-ethylamine; With trifluoroacetic acid; In toluene; at 140 ℃; for 0.5h; Microwave irradiation;

With sodium hydroxide; In water; pH=8; Cooling;
DOI:10.1021/jo100980p

Reference yield: 98.0%

: 10172-51-7
6,7-dimethoxy-1-phenyl-3,4-dihydroisoquinoline

: 4118-36-9
6,7-dimethoxy-1-phenyl-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: With trimethylamine-N-oxide; (N,N,N-trimethyl-2-(5-oxo-4,6-bis(trimethylsilyl)cyclopenta[c]pyrrol-2-(1H,3H,5H)-yl)ethanaminium) iron tricarbonyl; hydrogen; In water; at 100 ℃; for 14h; under 7500.75 Torr; Reagent/catalyst; Autoclave; Inert atmosphere;
DOI:10.1002/cctc.201300325