Technology Process of 3-Quinolinecarboxylic acid,
1-ethyl-1,4-dihydro-7-(1H-imidazol-1-ylphenylmethyl)-6-methoxy-4-oxo-,
ethyl ester
There total 9 articles about 3-Quinolinecarboxylic acid,
1-ethyl-1,4-dihydro-7-(1H-imidazol-1-ylphenylmethyl)-6-methoxy-4-oxo-,
ethyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
potassium carbonate;
In
N,N-dimethyl-formamide;
1.) 40 deg C, 12 h, 2.) r.t., 15 h;
DOI:10.1002/jhet.5570240220
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 94 percent / KF / dimethylsulfoxide / 15 h / Heating
2: 74 percent / NaBH4, 10percent NaOH / 5 h / Ambient temperature
3: 97 percent / SOBr2 / diethyl ether / 12 h / Heating
4: 44 percent / triethylamine / acetonitrile / 24 h / Heating
5: 85 percent / H2 / Pd/charcoal / methanol / 1 h / 1551.4 Torr / Ambient temperature
6: 89 percent / ethanol / 20 h / Heating
7: 70 percent / polyphosphoric acid, phosphoryl chloride / 4 h / 70 °C
8: 52 percent / K2CO3 / dimethylformamide / 1.) 40 deg C, 12 h, 2.) r.t., 15 h
With
potassium fluoride; sodium hydroxide; sodium tetrahydroborate; sulfurous dibromide; PPA; hydrogen; potassium carbonate; triethylamine; trichlorophosphate;
palladium on activated charcoal;
In
methanol; diethyl ether; ethanol; dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1002/jhet.5570240220
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 74 percent / NaBH4, 10percent NaOH / 5 h / Ambient temperature
2: 97 percent / SOBr2 / diethyl ether / 12 h / Heating
3: 44 percent / triethylamine / acetonitrile / 24 h / Heating
4: 85 percent / H2 / Pd/charcoal / methanol / 1 h / 1551.4 Torr / Ambient temperature
5: 89 percent / ethanol / 20 h / Heating
6: 70 percent / polyphosphoric acid, phosphoryl chloride / 4 h / 70 °C
7: 52 percent / K2CO3 / dimethylformamide / 1.) 40 deg C, 12 h, 2.) r.t., 15 h
With
sodium hydroxide; sodium tetrahydroborate; sulfurous dibromide; PPA; hydrogen; potassium carbonate; triethylamine; trichlorophosphate;
palladium on activated charcoal;
In
methanol; diethyl ether; ethanol; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1002/jhet.5570240220
