4H-Pyrido[1,2-a]pyrimidine-3-carboxaldehyde, 4-oxo-2-(1-pyrrolidinyl)-

Base Information

• Chemical Name: 4H-Pyrido[1,2-a]pyrimidine-3-carboxaldehyde, 4-oxo-2-(1-pyrrolidinyl)-
• CAS No.: 111680-73-0
• Molecular Formula: C13H13N3O2
• Molecular Weight: 243.26100
• DSSTox Substance ID: DTXSID70355251
• Nikkaji Number: J2.423.369C
• Wikidata: Q82134023
• Mol file: 111680-73-0.mol

Synonyms:111680-73-0;4H-Pyrido[1,2-a]pyrimidine-3-carboxaldehyde, 4-oxo-2-(1-pyrrolidinyl)-;4-oxo-2-(pyrrolidin-1-yl)-4H-pyrido[1,2-a]pyrimidine-3-carbaldehyde;4-oxo-2-pyrrolidin-1-ylpyrido[1,2-a]pyrimidine-3-carbaldehyde;4-Oxo-2-pyrrolidin-1-yl-4H-pyrido[1,2-a]-pyrimidine-3-carbaldehyde;Oprea1_116066;Oprea1_125730;DTXSID70355251;4-Oxo-2-pyrrolidin-1-yl-4H-pyrido[1,2-a]pyrimidine-3-carbaldehyde;STK821520;AKOS000301729;CS-0325253;4-OXO-2-(1-PYRROLIDINYL)-4H-PYRIDO(1,2-A)PYRIMIDINE-3-CARBALDEHYDE

Chemical Property of 4H-Pyrido[1,2-a]pyrimidine-3-carboxaldehyde, 4-oxo-2-(1-pyrrolidinyl)-

Chemical Property:

• PSA: 54.68000
• LogP: 1.17220
• XLogP3: 0.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 243.100776666
• Heavy Atom Count: 18
• Complexity: 522

Purity/Quality:

98%min ^*data from raw suppliers

4-Oxo-2-pyrrolidin-1-yl-4H-pyrido[1,2-a]-pyrimidine-3-carbaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CCN(C1)C2=C(C(=O)N3C=CC=CC3=N2)C=O

Technology Process of 4H-Pyrido[1,2-a]pyrimidine-3-carboxaldehyde, 4-oxo-2-(1-pyrrolidinyl)-

There total 5 articles about 4H-Pyrido[1,2-a]pyrimidine-3-carboxaldehyde, 4-oxo-2-(1-pyrrolidinyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

2-(1-pirrolidinil)-4H-pirido<1,2-a>pirimidin-4-one (84292-30-8) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 2-(1-pyrrolidinyl)-4-oxo-4H-pyrido<1,2-a>pyrimidine-3-carbaldehyde (111680-73-0)

Guidance literature:

With trichlorophosphate; at 90 ℃; for 1h;

DOI:10.1016/S0040-4020(03)00593-3

Reference yield: 73.0%

pyrrolidine (123-75-1) + 2-chloro-4-oxo-4H-pyrido<1,2-a>pyrimidine 3-carboxaldehyde (17481-62-8) → 2-(1-pyrrolidinyl)-4-oxo-4H-pyrido<1,2-a>pyrimidine-3-carbaldehyde (111680-73-0)

Guidance literature:

With triethylamine; In tetrahydrofuran; at 20 ℃; for 3h;

DOI:10.1016/S0040-4020(03)00593-3

Reference yield:

4-oxo-2-(pyrrolidin-1-yl)-4H-pyrido[1,2-a]pyrimidine-3-carbaldehyde phenylhydrazone (596815-04-2) → 2-(1-pyrrolidinyl)-4-oxo-4H-pyrido<1,2-a>pyrimidine-3-carbaldehyde (111680-73-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 84 percent / pyridinium p-toluenesulfonate / benzene / 20 h / Heating

2: 77 percent / POCl₃ / 1 h / 90 °C

With pyridinium p-toluenesulfonate; trichlorophosphate; In benzene;

DOI:10.1016/S0040-4020(03)00593-3

upstream raw materials:

2-(1-pirrolidinil)-4H-pirido<1,2-a>pirimidin-4-one

pyrrolidine

2-chloro-4-oxo-4H-pyrido<1,2-a>pyrimidine 3-carboxaldehyde

N,N-dimethyl-formamide

Downstream raw materials:

4-oxo-2-(pyrrolidin-1-yl)-4H-pyrido[1,2-a]pyrimidine-3-carbaldehyde phenylhydrazone