Ethanone, 1-phenyl-2-(1,3,4,9-tetrahydro-2H-pyrido[3,4-b]indol-2-yl)-

Base Information

• Chemical Name: Ethanone, 1-phenyl-2-(1,3,4,9-tetrahydro-2H-pyrido[3,4-b]indol-2-yl)-
• CAS No.: 111733-93-8
• Molecular Formula: C19H18N2O
• Molecular Weight: 290.365
• DSSTox Substance ID: DTXSID50471089
• Mol file: 111733-93-8.mol

Synonyms:111733-93-8;2-(3,4-dihydro-1H-pyrido[3,4-b]indol-2(9H)-yl)-1-phenylethanone;Ethanone, 1-phenyl-2-(1,3,4,9-tetrahydro-2H-pyrido[3,4-b]indol-2-yl)-;DTXSID50471089

Chemical Property of Ethanone, 1-phenyl-2-(1,3,4,9-tetrahydro-2H-pyrido[3,4-b]indol-2-yl)-

Chemical Property:

• XLogP3: 3.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 290.141913202
• Heavy Atom Count: 22
• Complexity: 404

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CN(CC2=C1C3=CC=CC=C3N2)CC(=O)C4=CC=CC=C4

Technology Process of Ethanone, 1-phenyl-2-(1,3,4,9-tetrahydro-2H-pyrido[3,4-b]indol-2-yl)-

There total 1 articles about Ethanone, 1-phenyl-2-(1,3,4,9-tetrahydro-2H-pyrido[3,4-b]indol-2-yl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

tetrahydrobetacarboline (16502-01-5) + α-bromoacetophenone (70-11-1) → α-(1,2,3,4-Tetrahydro-β-carbolin-2-yl)-acetophenon (111733-93-8)

Guidance literature:

In tetrahydrofuran; for 1h;

DOI:10.1007/BF00809930

Reference yield: 67.0%

α-(1,2,3,4-Tetrahydro-β-carbolin-2-yl)-acetophenon (111733-93-8) + methylhydrazine (60-34-4) → 2-(1,2,3,4-Tetrahydro-9H-pyrido<3,4-b>indol-2-yl)-N-methyl-acetophenonhydrazon

Guidance literature:

DOI:10.1002/ardp.19873200313

Reference yield: 66.0%

2-azido-3-(4-chlorophenyl)-1-phenylprop-2-en-1-one + α-(1,2,3,4-Tetrahydro-β-carbolin-2-yl)-acetophenon (111733-93-8) → 1-(4-chlorophenyl)-4,5,10,10b-tetrahydro-1H-azirino[1'',2'':3',4']imidazo[1',2':1,2]pyrido[3,4-b]indole-1a,2(2H)-diylbis(phenylmethanone)

Guidance literature:

With tert.-butylhydroperoxide; tris(2,2-bipyridine)ruthenium(II) hexafluorophosphate; In toluene; acetonitrile; at 20 ℃; for 24h; Irradiation;

DOI:10.1021/acs.orglett.6b01321

upstream raw materials:

tetrahydrobetacarboline

α-bromoacetophenone

Downstream raw materials:

(Z)-α-(1,2,3,4-Tetrahydro-β-carbolin-2-yl)-acetophenonoxim

(E)-α-(1,2,3,4-Tetrahydro-β-carbolin-2-yl)-acetophenonoxim

6,7,12,12b-Tetrahydro-3-phenyl-4H-<1,2,5>-oxadiazino<5',6':1,2>pyrido<3,4-b>indol

3,5,6,11b-Tetrahydro-2-phenyl-11H-imidazo<1',2':1,2>pyrido<3,4-b>indol-1-oxid