3,5-DIMETHYLBENZYLMAGNESIUM BROMIDE

Base Information

• Chemical Name: 3,5-DIMETHYLBENZYLMAGNESIUM BROMIDE
• CAS No.: 111823-36-0
• Molecular Formula: C9H11BrMg
• Molecular Weight: 223.395
• Mol file: 111823-36-0.mol

Synonyms:3,5-dimethyl-benzyl magnesium (1+),bromide;3,5-Dimethylbenzylmagnesium bromide 0.25 M in Tetrahydrofuran;3,5-Dimethyl-benzylmagnesium(1+),Bromid;3,5-dimethylphenylmethylmagnesium bromide;3,5-dimethylbenzylmagnesium chloride;3,5-dimethylbenzylmagnesium bromide;Magnesium,bromo[(3,5-dimethylphenyl)methyl];

Chemical Property of 3,5-DIMETHYLBENZYLMAGNESIUM BROMIDE

Chemical Property:

• PSA: 0.00000
• LogP: -0.23040

Purity/Quality:

97% ^*data from raw suppliers

3,5-Dimethylbenzylmagnesiumbromide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3,5-DIMETHYLBENZYLMAGNESIUM BROMIDE

There total 1 articles about 3,5-DIMETHYLBENZYLMAGNESIUM BROMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-bromomethyl-3,5-dimethylbenzene (27129-86-8) → [(3,5-dimethylphenyl)methyl]magnesium bromide (111823-36-0)

Guidance literature:

With diethyl ether;

Reference yield: 89.0%

Gallium trichloride (13450-90-3) + [(3,5-dimethylphenyl)methyl]magnesium bromide (111823-36-0) → [GaBr(CH2C6H3(CH3)2)2]2

Guidance literature:

In diethyl ether; byproducts: MgCl2, MgBr2; (argon); reflux (4 h); removal of solvent (vac.), trituration with toluene, filtration, crystn.upon concn.; elem. anal.;

Reference yield: 68.0%

[(3,5-dimethylphenyl)methyl]magnesium bromide (111823-36-0) + N-methoxy-N-methyl-3-((4-methylphenyl)sulfonamido)propanamide (193635-17-5) → N-(4-(3,5-dimethylphenyl)-3-oxobutyl)-4-methylbenzenesulfonamide

Guidance literature:

In tetrahydrofuran; at 20 ℃; for 2h; Inert atmosphere;

DOI:10.1002/anie.202108589

upstream raw materials:

1-bromomethyl-3,5-dimethylbenzene

Downstream raw materials:

2,4,6-trimethylbenzyl alcohol

bis-(2,4,6-trimethyl-benzyl)-ether

2-(3,5-dimethylbenzyl)-4-(5-fluoro-2-methoxyphenyl)-2-hydroxy-4-methylpentanoic acid (1-oxo-1,3-dihydroisobenzofuran-5-yl)amide

1-(3,5-dimethylphenyl)-5-(5-fluoro-2-methoxyphenyl)-3-methoxymethoxy-5-methyl-3-trifluoromethylhexan-2-ol