Hydroxylamine, O-benzoyl- (6CI,7CI,9CI)

Base Information

• Chemical Name: Hydroxylamine, O-benzoyl- (6CI,7CI,9CI)
• CAS No.: 54495-98-6
• Molecular Formula: C7H7 N O2
• Molecular Weight: 137.138
• Hs Code.: 2922199090
• Mol file: 54495-98-6.mol

Synonyms:Hydroxylamine,O-benzoyl- (6CI,7CI,9CI); O-Benzoylhydroxylamine

Chemical Property of Hydroxylamine, O-benzoyl- (6CI,7CI,9CI)

Chemical Property:

• Melting Point: 116 °C (decomp)
• Boiling Point: 236.0±23.0 °C(Predicted)
• PKA: 0.19±0.70(Predicted)
• PSA: 52.32000
• Density: 1 +-.0.06 g/cm3(Predicted)
• LogP: 1.41740

Purity/Quality:

99% ^*data from raw suppliers

Benzoicacidazanylester 97.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Hydroxylamine, O-benzoyl- (6CI,7CI,9CI)

There total 9 articles about Hydroxylamine, O-benzoyl- (6CI,7CI,9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

p-nitrophenylbenzoate (959-22-8) → Benzohydroxamic acid (495-18-1) + O-Benzoylhydroxylamine (54495-98-6)

Guidance literature:

With ethanol; hydroxylamine;

DOI:10.1021/ja01550a041

Reference yield:

(benzyloxy)carbamic acid 1,1-dimethylethyl ester (105340-85-0) → O-Benzoylhydroxylamine (54495-98-6)

Guidance literature:

With hydrogenchloride; nitromethane;

DOI:10.1021/ja01513a049

Reference yield:

benzoyl chloride (98-88-4) → O-Benzoylhydroxylamine (54495-98-6)

Guidance literature:

Multi-step reaction with 2 steps

1: Py / diethyl ether

2: H₂O, HCl / diethyl ether

With pyridine; hydrogenchloride; water; In diethyl ether;

upstream raw materials:

(benzyloxy)carbamic acid 1,1-dimethylethyl ester

p-nitrophenylbenzoate

ethyl O-benzoyl acetohydroxamate

C₁₀H₁₁NO₃

Downstream raw materials:

o-azidonitrobenzene

N-acetyl-O-benzoylhydroxylamine

Acetone O-benzoyloxime

benzoic acid

Refernces

Amination of heterocyclic compounds with O-benzoylhydroxylamine derivatives

10.1021/ol701730r

In the research, O-benzoylhydroxylamine derivatives play a crucial role as aminating agents. These compounds are used to transfer an amino group (NH2) to various heterocyclic compounds, such as pyrroles, indoles, imidazoles, pyrazoles, and carbazoles. The study investigates the structure-reactivity relationship of different O-benzoylhydroxylamine derivatives to identify more efficient reagents for the N-amination process. The derivatives are synthesized from corresponding benzoyl chlorides and hydroxylamine, and their reactivity is evaluated based on their ability to convert heterocyclic substrates into the desired N-aminated products. The research highlights the discovery of novel and more efficient aminating reagents, such as 5h and 5i, which provide higher conversions and better stability compared to the previously used 5a. These findings suggest that O-benzoylhydroxylamine derivatives can serve as practical and superior alternatives for the N-amination of heterocyclic compounds in organic synthesis.

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